3β-[(α-L-arabinopyranosyl)oxy]-20β-hydroxyursan-28-oic acid δ-lactone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-[(α-L-arabinopyranosyl)oxy]-20β-hydroxyursan-28-oic acid δ-lactone
• 化学式: C₃₅H₅₆O₇
• 分子量: 588.825
• InChiKey: CLBUFPVIPPZYGO-LCIDBVSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.23
• 重原子数：
  42.0
• 可旋转键数：
  2.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  105.45
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  3β-[(α-L-arabinopyranosyl)oxy]-20β-hydroxyursan-28-oic acid δ-lactone 在 盐酸 、 水 作用下， 反应 2.0h， 生成 L-(+)-arabinose
  参考文献：
  名称：

  Anti-inflammatory Triterpenes from the Leaves of Rosa laevigata

  摘要：

  Bioassay-guided fractionation of an EtOAc extract of the leaves of Rosa laevigata afforded two new 19-oxo-18,19-seco-ursane-type triterpenes (1 and 3), a new ursane-type nortriterpene (2), a new ursane-type triterpene lactone saponin (4), and two new oleanane-type triterpenoids (5 and 6), together with eight known triterpenoids. (7-14). Compound 1, a 19-oxo-18,19-seco-28-norursane, possesses' a conjugated diene between C-12 and C-17. Several of the isolated compounds (1, 5, 7, 11, and 13) exhibited moderate activities in anti-inflammatory assays in vitro.

  DOI：

  10.1021/np1007922

文献信息

• Anti-inflammatory Triterpenes from the Leaves of <i>Rosa laevigata</i>
  作者：Na Zeng、Yang Shen、Ling-Zhi Li、Wei-Hua Jiao、Pin-Yi Gao、Shao-Jiang Song、Wan-Sheng Chen、Hou-Wen Lin

  DOI：10.1021/np1007922

  日期：2011.4.25

  Bioassay-guided fractionation of an EtOAc extract of the leaves of Rosa laevigata afforded two new 19-oxo-18,19-seco-ursane-type triterpenes (1 and 3), a new ursane-type nortriterpene (2), a new ursane-type triterpene lactone saponin (4), and two new oleanane-type triterpenoids (5 and 6), together with eight known triterpenoids. (7-14). Compound 1, a 19-oxo-18,19-seco-28-norursane, possesses' a conjugated diene between C-12 and C-17. Several of the isolated compounds (1, 5, 7, 11, and 13) exhibited moderate activities in anti-inflammatory assays in vitro.