3-（二异丙基膦基）丙胺 | 1196147-69-9

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 中文名称: 3-（二异丙基膦基）丙胺
• 中文别名: 3-(二异丙基膦基)丙基胺
• 英文名称: 3-(di-i-propylphosphino)propylamine
• 英文别名: 3-(di-isopropylphosphanyl)-1-aminopropane；3-(diisopropylphosphino)propanamine；3-(DI-I-Propylphosphino)propylamine；3-di(propan-2-yl)phosphanylpropan-1-amine
• CAS: 1196147-69-9
• 化学式: C₉H₂₂NP
• 分子量: 175.254
• InChiKey: RVKSUPMPCDJZRG-UHFFFAOYSA-N

物化性质

• 暴露限值：
  ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)OSHA: TWA 200 ppm(590 mg/m3)NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-（二异丙基膦基）丙胺 以 四氢呋喃 为溶剂， 反应 7.0h， 生成
  参考文献：
  名称：

  Cobalt Phosphino-α-Iminopyridine-Catalyzed Hydrofunctionalization of Alkenes: Catalyst Development and Mechanistic Analysis

  摘要：

  A family of CoCl2(PNpy) complexes were prepared, where PNpy = 2-iminopyridyl-phosphine ligands derived from amino-alkyl and aminoaryl phosphines and 2-keto- and 2-formylpyridines. Reduction of CoCl2(PNpy) complexes in the presence of PPh3 gave CoH(PNpy)(PPh3) and CoMe(PNpy)(PPh3), which were active for hydrofunctionalization of alkenes. According to DFT calculations, the CoMe(PNpy)(PPh3) complexes are best described as Co (II) derivatives of the anion [PNpy](-), with a labile PPh3 coligand. Metalation of Na[(Ph2)PC(2)N(H)py] gave the dimers [CoCl2(P(C2)N(H)py)](2). Monomeric complexes catalyze hydrosilylation of 1-octene with Ph2SiH2, with the CoCl2 ((iPr2)P(C3)N(H)py)/2NaBEt(3)H system exhibiting the highest rate and selectivity for anti-Markovnikov product. In situ NMR studies established the following: (i) silanes protonolyze catalyst precursors to give the. Co-silylcomplexes Co (SiR3) ((Ph2)P(C6H4)N(Ph)py)(pph(3)), (ii) alkenes compete with PPh3 to give Co(SiHPh2)((Ph2)P(C6H4)N(Ph)py) (eta(2)-alkene), (iii) ethylene inserts into the Co-Si bond to give Co(CH2CH3SiR3)((Ph2)P(C6H4)N(Ph)py)(pph(3)).

  DOI：

  10.1021/acs.organomet.6b00457
• 作为产物：
  描述：

  在 硫酸 、 水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 3-（二异丙基膦基）丙胺
  参考文献：
  名称：

  Aminophosphine ligands R2P(CH2)nNH2 and ruthenium hydrogenation catalysts RuCl2(R2P(CH2)nNH2)2

  摘要：

  氨基膦配体R2P(CH2)2NH2和R2P(CH2)3NH2（R = Ph，iPr，tBu）分别通过LiPR2与Cl(CH2)2N(TMS)2和Cl(CH2)3N(TMS)2反应后水解，以良好的至优异的产率被分离出来。这种方法通过改变膦上的取代基，可以精细调节配体的立体电子性质。利用这些氨基膦配体，通过在适当溶剂中将相应的配体与[RuCl2(cod)]n按2:1混合反应，制备了钌配合物RuCl2(R2P(CH2)2NH2)2和RuCl2(R2P(CH2)3NH2)2。所得配合物被发现是酮和亚胺氢化的优异催化剂。

  DOI：

  10.1039/b911459a

文献信息

• NNP-Type Pincer Imidazolylphosphine Ruthenium Complexes: Efficient Base-Free Hydrogenation of Aromatic and Aliphatic Nitriles under Mild Conditions
  作者：Rosa Adam、Elisabetta Alberico、Wolfgang Baumann、Hans-Joachim Drexler、Ralf Jackstell、Henrik Junge、Matthias Beller

  DOI：10.1002/chem.201504709

  日期：2016.3.24

  seven novel NImNHP‐type pincer imidazolylphosphine ruthenium complexes has been synthesized and fully characterized. The use of hydrogenation of benzonitrile as a benchmark test identified [RuHCl(CO)(NImNHPtBu)] as the most active catalyst. With its stable Ru−BH4 analogue, in which chloride is replaced by BH4, a broad range of (hetero)aromatic and aliphatic nitriles, including industrially interesting

  已合成并充分表征了一系列七个新型的N Im N H P型钳型咪唑基膦膦钌配合物。使用苯甲腈加氢作为基准测试，确定了[RuHCl（CO）（N Im N H P t Bu）]是最具活性的催化剂。凭借其稳定的Ru-BH 4类似物（其中氯化物被BH 4替代），已在温和且无碱的条件下氢化了多种（杂）芳族和脂肪族腈，包括工业上有用的己二腈。
• Carbonyl and ester C–O bond hydrosilylation using κ⁴-diimine nickel catalysts
  作者：Christopher L. Rock、Thomas L. Groy、Ryan J. Trovitch

  DOI：10.1039/c8dt01857j

  日期：——

  complete ester C–O bond hydrosilylation was observed within 30 min at 25 °C to generate propylene and PhSi(OAc)3. The scope of this reaction was expanded to include six additional allyl esters, and under neat conditions, turnover frequencies of up to 990 h−1 were achieved. This activity is believed to be the highest reported for transition metal-catalyzed ester C–O bond hydrosilylation. Proposed mechanisms

  烷基膦取代的α-二亚胺（DI）配体的合成及其随后添加到Ni（COD）2中允许制备（iPr2PPr DI）Ni和（tBu2PPr DI）Ni。发现这两种化合物的固态结构都具有扭曲的四面体几何形状，这与已报道的二苯基膦取代的变体（Ph 2 PPr DI）Ni的结构基本一致。为了探索和优化此类催化剂的合成效用，在25°C的3小时内，以1.0 mol％的负载量对三种化合物的苯甲醛氢化硅烷化活性进行了筛选。值得注意的是，（Ph 2发现PPr DI）Ni是最有效的催化剂，而苯基硅烷是最有效的还原剂。然后将大范围的醛和酮氢化硅烷化，并将甲硅烷基醚产物水解以提供高收率的醇。当尝试探索酯的还原时，发现乙酸乙酯的二氢甲硅烷基化效率低下，另外几种底物也未观察到反应。但是，当将乙酸烯丙酯和苯基硅烷的等摩尔溶液添加到1.0 mol％（ Ph 2 PPr DI）Ni中时，在25°C的30分钟内观察到完全的酯C–O键氢化硅烷化生成丙烯和PhSi（OAc）
• Synthesis, characterization, DFT optimization and anticancer evaluation of phosphanegold(I) dithiocarbamates
  作者：Adam A. Sulaiman、Wiktor Zierkiewicz、Mariusz Michalczyk、Magdalena Malik-Gajewska、Saeed Ahmad、Ali Alhoshani、Homood M. As Sobeai、Dariusz Bieńko、Anvarhusein A. Isab

  DOI：10.1016/j.molstruc.2020.128486

  日期：2020.10

  Abstract Six phosphanegold(I)-dithiocarbamate complexes (1–6) of general formula [Au(L)(S2CNR2)] (where L = 2-(di-isopropylphosphanyl)-1-aminoethane (AEP) and 3-(di-isopropylphosphanyl)-1-aminopropane (APP), and R = methyl, ethyl, benzyl) were prepared by the reactions of equimolar amounts of (CH3)2S–AuCl, phosphanes and dithiocarbamates (S2CNR2) in dichloromethane. The complexes were characterized

  摘要 六种具有通式 [Au(L)(S2CNR2)]（其中 L = 2-（二-异丙基膦酰基）-1-氨基乙烷 (AEP) 和 3-(di-通过等摩尔量的 (CH3)2S–AuCl、膦和二硫代氨基甲酸酯 (S2CNR2) 在二氯甲烷中的反应制备异丙基膦基）-1-氨基丙烷（APP）和 R = 甲基、乙基、苄基）。通过元素分析、FTIR和NMR光谱表征配合物。使用 DFT（密度泛函理论）方法在气相和氯仿溶液中理论上预测了配合物的结构。研究了复合物对三种人类癌细胞系的体外细胞毒性；A549、HeLa 和 HepG2。在大多数情况下，配合物的抑制作用小于顺铂。
• [EN] METHOD FOR PRODUCING AMIDINE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRODUCTION DE DÉRIVÉS D'AMIDINE
  申请人：BIOCRYST PHARM INC

  公开号：WO2016029216A2

  公开（公告）日：2016-02-25

  The invention provides methods and intermediates useful in the synthesis of a compound of formula (I): or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof; wherein the variables are as defined herein.

  本发明提供了用于合成式(I)化合物的方法和中间体，或其药学上可接受的盐、溶剂和前药酯；其中变量如本文所定义。
• Efficient Hydrogenation of N‐Heterocycles Catalyzed by NNP–Manganese(I) Pincer Complexes at Ambient Temperature
  作者：Veronica Papa、Johannes Fessler、Francesco Zaccaria、Julien Hervochon、Phong Dam、Christoph Kubis、Anke Spannenberg、Zhihong Wei、Haijun Jiao、Cristiano Zuccaccia、Alceo Macchioni、Kathrin Junge、Matthias Beller

  DOI：10.1002/chem.202202774

  日期：2023.1.9

  Several NImNHP-Mn(I) pincer complexes were synthesised and studied by a combination of experimental and theoretical investigations. Their interesting catalytic activities were shown in several hydrogenation reactions of N-heterocycles with good to excellent performance under very mild conditions.

  通过实验和理论研究相结合，合成并研究了几种 N Im N H P-Mn(I) 钳配合物。它们在几个 N-杂环加氢反应中表现出有趣的催化活性，在非常温和的条件下具有良好至优异的性能。