2,5-Cyclohexadiene-1-one | 129664-75-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Cyclohexadiene-1-one
• 英文别名: 2-methoxy-4-(2-propenylidene)-2,5-cyclohexadien-1-one, E-isomer；E-2-methoxy-4-(2-propylidene)-2,5-cyclohexadiene-1-one；2-Methoxy-4-allylidene-2,5-cyclohexadiene-1-one；(4E)-2-methoxy-4-prop-2-enylidenecyclohexa-2,5-dien-1-one
• CAS: 129664-75-1
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.188
• InChiKey: CDFKJSCCQGJMHM-XBXARRHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-甲氧基儿茶酚 、 2,5-Cyclohexadiene-1-one 在 对甲苯磺酸 作用下， 以 氯仿 为溶剂， 以126 mg的产率得到3-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl]-6-methoxybenzene-1,2-diol
  参考文献：
  名称：

  Synthetic cinnamylphenol derivatives as cancer chemopreventive agents

  摘要：

  Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.12.024
• 作为产物：
  描述：

  丁香酚 在 silver(l) oxide 作用下， 以 氯仿 为溶剂， 生成 2,5-Cyclohexadiene-1-one
  参考文献：
  名称：

  Synthetic cinnamylphenol derivatives as cancer chemopreventive agents

  摘要：

  Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.12.024

文献信息

• A theoretical and experimental investigation of Z, E stereoisomerism in some simple lignin p-quinone methides
  作者：Henrik Konschin、Juris Jakobsons、Sergey M. Shevchenko

  DOI：10.1016/0022-2860(90)85017-d

  日期：1990.10
• Shevchenko, S. M.; Semenov, S. G.; Evstigneev, E. I., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, # 9, p. 1679 - 1688
  作者：Shevchenko, S. M.、Semenov, S. G.、Evstigneev, E. I.、Pranovich, A. V.、Gindin, V. A.

  DOI：——

  日期：——
• [EN] COMPOSITE MATERIAL COMPRISING A WATER- OR ACID-RELEASING AGENT<br/>[FR] MATÉRIAU COMPOSITE COMPRENANT UN AGENT DE LIBÉRATION D'EAU OU D'ACIDE
  申请人：DENTOFIT AS

  公开号：WO2007104312A2

  公开（公告）日：2007-09-20

  [EN] The present invention discloses a composite material comprising one or more fillers and a polymerizable resin base, wherein said one or more fillers comprise at least one filler ingredient, said filler ingredient(s) being present in a metastable first phase and being able to undergo a martensitic transformation to a stable second phase, the volume ratio between said stable second phase and said metastable first phase of said filler ingredient(s) being at least 1.005, and wherein said material further comprises one or more water- or acid- releasing agents; as well as a corresponding method of controlling the volumetric shrinkage of a composite material upon curing.
  [FR] L'invention porte sur un matériau composite comportant une ou plusieurs charges et une base de résine polymérisable. La ou les charges comportent au moins un ingrédient présent dans une première phase métastable et susceptible de subir une transformation martensitique en une deuxième phase stable, le rapport volumique entre ladite deuxième phase stable et ladite première phase métastable étant d'au moins 1,005, ledit matériau comportant en outre un ou des agents de libération d'eau ou d'acide. L'invention porte par ailleurs sur un procédé associé de régulation de la contraction volumique d'un matériau composite lors de sa prise.
• Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
  作者：Chihiro Ito、Masataka Itoigawa、Tetsufumi Kanematsu、Yuuki Imamura、Harukuni Tokuda、Hoyoku Nishino、Hiroshi Furukawa

  DOI：10.1016/j.ejmech.2006.12.024

  日期：2007.7

  Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters). (c) 2007 Elsevier Masson SAS. All rights reserved.