(3R,3aR,5aS,6R,7S,9aS,9bS)-6-(2-iodoethyl)-3a,6-dimethyl-3-[(2R)-6-methylheptan-2-yl]spiro[1,2,3,4,5,5a,8,9,9a,9b-decahydrocyclopenta[a]naphthalene-7,3'-pyrrolidine]-2',5'-dione | 122913-37-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3R,3aR,5aS,6R,7S,9aS,9bS)-6-(2-iodoethyl)-3a,6-dimethyl-3-[(2R)-6-methylheptan-2-yl]spiro[1,2,3,4,5,5a,8,9,9a,9b-decahydrocyclopenta[a]naphthalene-7,3'-pyrrolidine]-2',5'-dione
• CAS: 122913-37-5
• 化学式: C₂₈H₄₆INO₂
• 分子量: 555.583
• InChiKey: LURFYLFSQTZCBE-YWYWTDKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-胆甾烯-3-酮 在 4,4-二碘联苯 碘 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 (3R,3aR,5aS,6R,7S,9aS,9bS)-6-(2-iodoethyl)-3a,6-dimethyl-3-[(2R)-6-methylheptan-2-yl]spiro[1,2,3,4,5,5a,8,9,9a,9b-decahydrocyclopenta[a]naphthalene-7,3'-pyrrolidine]-2',5'-dione
  参考文献：
  名称：

  高价有机碘试剂在双环羧酰胺的β片段化反应中导致酰亚胺

  摘要：

  描述了在（二乙酰氧基碘）-苯和碘存在下，通过光解双环[3.3.0]-和[3.2.1]-碳氨酰胺合成3,4-取代的环酰亚胺的温和简便的方法。

  DOI：

  10.1016/s0040-4039(00)82424-7

文献信息

• Syntheses of Substituted Succinimides by Radical .beta.-Fragmentation of Bicyclic Carbinol Amides. A New Expeditious Synthesis of 2-[2-(Methoxycarbonyl)ethyl]-3-[(methoxycarbonyl)methyl]- 3-methylsuccinimide, the Ring-B Imide of Vitamin B12
  作者：Rosendo Hernandez、Ernesto Suarez、Daniel Melian

  DOI：10.1021/jo00089a021

  日期：1994.5

  A mild and efficient synthesis of substituted succinimides by radical beta-fragmentation of carbinol amides is described. The carbinol amides studied were generated by treatment of the corresponding alpha,beta-unsaturated ketones with hydrogen cyanide and subsequent hydrolysis of the cyanide intermediates. Photolysis with visible light in the presence of (diacetoxyiodo)benzene (DIB) and iodine of azabicyclic carbinol amides of the types 1-hydroxy-2-azabicyclo[3.3.0] octan-3-one (e.g., 4, 6, and 7) and 1-hydroxy-2-azabicyclo[3.2.1]octan-3-one (e.g., 16, 17, and 21) led to the substituted succinimides in good yields. A novel and operationally simple synthesis of the ring-B imide 28 is described, employing this P-fragmentation reaction on the carbinol amide 7 as the key step. The transformation of the resulting succinimide 11 into the target 28 was accomplished in one step by oxidation of the primary iodide and the phenyl group with RUO(4).
• Hypervalent organoiodine reagents in the β-fragmentation of bicyclic carbinolamides leading to imides
  作者：R. Hernández、J.J. Marrero、D. Melián、E. Suárez

  DOI：10.1016/s0040-4039(00)82424-7

  日期：1988.1

  A mild and convenient method for the synthesis of 3,4-substituted cyclic imides by photolysis of bicyclic [3.3.0]- and [3.2.1]-carbinolamides in the presence of (diacetoxyiodo)-benzene and iodine is described.

  描述了在（二乙酰氧基碘）-苯和碘存在下，通过光解双环[3.3.0]-和[3.2.1]-碳氨酰胺合成3,4-取代的环酰亚胺的温和简便的方法。