在硝酸介质中以高tech酸根阴离子形式存在的tech的提取是用于回收铀和p的溶剂提取过程中的一个问题。在本研究中,将络合剂添加到硝酸水溶液中以选择性地结合高net酸酯阴离子,并防止其提取到有机相中或将其反提取到水相中。合成了几种带有亲水基团的氮杂聚糖,以改善先前研究的笼状分子在硝酸介质中的溶解度。溶剂萃取试验表明,所有合成的配体对高tech酸根都有相似的络合强度,并且能够在水相中保留该阴离子(0.5 M HNO 3)。这些配体能够克服霍夫迈斯特偏倚,并选择性结合硝酸溶液中的tech。与我们以前的工作相比,在液-液萃取条件下,氮杂聚糖的浓度可以增加三倍。使用微量量热法,单晶X射线衍射(SC-XRD),红外光谱和拉曼光谱学进行的配位研究表明,形成了具有氢键的包合物,稳定了腔体内的氧阴离子。这种溶解度的提高有望在溶剂萃取过程中引入这种大环氮杂聚糖。
COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
申请人:CHIESI FARMACEUTICI S.p.A.
公开号:US20160235734A1
公开(公告)日:2016-08-18
Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.
triangular macrocycles, whose constitution and symmetry depend on the structure of the aldehyde substrate. Formation of hexa-oxygenated trianglimine is highly stereoselective: that is, the use of racemic diamine yields a racemic mixture of homochiral triangular macrocycles, each having the same absoluteconfiguration at all stereogenic centers. However, no self-sorting is observed when a mixture of non-,
licorice, is the most promising antimalarial compound reported so far. In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from Crotalaria medicagenia, which exhibited antimalarial activity against Plasmodium falciparum. A library of 88 chalcones were synthesized and evaluated for their in vitro antimalarial activity. Among these, 67,
Resveratrol analogues present effective antileishmanial activity against promastigotes and amastigotes from distinct <i>Leishmania</i> species by multitarget action in the parasites
作者:Luciana Maria Ribeiro Antinarelli、Raissa Soares Meinel、Eduardo Antonio Ferraz Coelho、Adilson David da Silva、Elaine Soares Coimbra
DOI:10.1111/jphp.13177
日期:2019.11.8
OBJECTIVES The in vitro antileishmanial effect of analogues of resveratrol (AR) present in the N-aryl imines and N-aryl hydrazones series was investigated. In addition, possible parasite targets were evaluated. METHODS Antipromastigote activity of Leishmania amazonensis, L. braziliensis and L. infantum, as well as the cytotoxicity on macrophages was determined by MTT assay and L. braziliensis-infected