7-diethylaminomethyl-5-nitro-quinolin-8-ol | 74440-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-diethylaminomethyl-5-nitro-quinolin-8-ol
• 英文别名: 7-Diaethylaminomethyl-5-nitro-chinolin-8-ol；7-((Diethylamino)methyl)-5-nitro-8-quinolinol；7-(diethylaminomethyl)-5-nitroquinolin-8-ol
• CAS: 74440-56-5
• 化学式: C₁₄H₁₇N₃O₃
• 分子量: 275.307
• InChiKey: OEMTYXHXQYEFNU-UHFFFAOYSA-N

物化性质

• 熔点：
  205-206 °C (decomp)
• 沸点：
  447.3±45.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  82.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-diethylaminomethyl-5-nitro-quinolin-8-ol 在 镍 、 溶剂黄146 作用下， 生成 5-amino-7-diethylaminomethyl-quinolin-8-ol
  参考文献：
  名称：

  Antimalarial Agents. VII.¹ The Synthesis of Certain Quinolylaminoquinolinols Based Upon the Schönhöfer Theory

  摘要：

  DOI：

  10.1021/ja01652a067
• 作为产物：
  描述：

  聚合甲醛 、 5-硝基-8-羟基喹啉 、 二乙胺 在 乙醇 作用下， 生成 7-diethylaminomethyl-5-nitro-quinolin-8-ol
  参考文献：
  名称：

  Antimalarial Agents. VII.¹ The Synthesis of Certain Quinolylaminoquinolinols Based Upon the Schönhöfer Theory

  摘要：

  DOI：

  10.1021/ja01652a067

文献信息

• [EN] DENGUE AND WEST NILE VIRUS PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉASES DES VIRUS WEST NILE ET DE LA DENGUE
  申请人：UNIV GEORGETOWN

  公开号：WO2014164667A1

  公开（公告）日：2014-10-09

  Compounds and methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a compound as described herein. The methods are useful in treating and/or preventing Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus. Methods of inhibiting a Flavivirus protease in a cell are also provided.

  提供了一种治疗或预防受试者Flavivirus感染的化合物和方法。该方法包括向受试者施用本文所述的化合物的治疗有效量。这些方法对于治疗和/或预防Flavivirus感染非常有用，例如西尼罗河病毒、登革病毒和日本脑炎病毒。还提供了在细胞中抑制Flavivirus蛋白酶的方法。
• Movrin; Maysinger; Marok, Pharmazie, 1980, vol. 35, # 8, p. 458 - 460
  作者：Movrin、Maysinger、Marok

  DOI：——

  日期：——
• MOVRIN M.; MAYSINGER D.; MAROK E., PHARMAZIE, 1980, 35, NO 8, 358-360
  作者：MOVRIN M.、 MAYSINGER D.、 MAROK E.

  DOI：——

  日期：——
• SHCHEREV, A.;TODOROV, B.;VODENICHAROV, R., TR. N.-I. XIM.-FARM. IN-T, NRB, 1985, 15, 71-80
  作者：SHCHEREV, A.、TODOROV, B.、VODENICHAROV, R.

  DOI：——

  日期：——
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.