α-D-galactopyranosyl phosphate | 2520-52-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-D-galactopyranosyl phosphate
• 英文别名: β-D-galactose 1-phosphate；galactose 1-phosphate；α-D-Galactopyranose-1-phosphat；β-D-Galactose-1-phosphat；O¹-Phosphono-β-D-galactopyranose；[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
• CAS: 2520-52-7
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: HXXFSFRBOHSIMQ-PHYPRBDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  尿嘧啶核苷 、 α-D-galactopyranosyl phosphate 在 galactose-1-phosphate thymidylyltransferase magnesium 作用下， 反应 0.5h， 生成 uridine 5'-diphospho-β-D-galactose
  参考文献：
  名称：

  合成天然和“非天然”UDP-和 TDP-核苷酸糖的通用酶法

  摘要：

  DOI：

  10.1021/ja001444y
• 作为产物：
  描述：

  [(2R,3S,4S,5R,6S)-3,4,5-tribenzoyloxy-6-bis(phenylmethoxy)phosphoryloxyoxan-2-yl]methyl benzoate 在 palladium on activated charcoal sodium hydroxide 、 氢气 作用下， 生成 α-D-galactopyranosyl phosphate
  参考文献：
  名称：

  一种通过碘鎓离子辅助的硫糖苷活化合成1,2-反式糖基磷酸酯的方法

  摘要：

  在除去所有保护基团后，在NIS存在下用磷酸二苄基酯对苯甲酰化的1,2-反式1-硫代1-硫代糖苷进行磷酸化，得到1,2-反式糖基磷酸酯。立体选择性方法的范围是由GDP-岩藻糖的合成，所述二糖α-d-GLC证实p（1→3）-α-L-鼠李糖- p -1-PO 4 - 。

  DOI：

  10.1016/0040-4039(91)80782-2

文献信息

• Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and "unnatural" UDP- and TDP-nucleotide sugars
  申请人：——

  公开号：US20030055235A1

  公开（公告）日：2003-03-20

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了一种突变型核苷酸转移酶，如E p ，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或修饰的Ep或其他核苷酸转移酶合成所需的核苷酸糖的方法；以及通过本发明方法合成的核苷酸糖。本发明进一步提供了新的糖基磷酸酯，及其制造方法。
• Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates
  作者：Chao Chen、Jef Van der Borght、Rob De Vreese、Matthias D'hooghe、Wim Soetaert、Tom Desmet

  DOI：10.1039/c4cc02202e

  日期：——

  A variant of trehalose phosphorylase was created that displays a modified specificity and can be used for the anomeric phosphorylation of galactose in a two-step process.

  创建了一种变体的海藻糖磷酸化酶，它显示出修改后的特异性，并可用于在两步过程中对半乳糖进行异构磷酸化。
• ACTIVE-SITE ENGINEERING OF NUCLEOTIDYLYLTRANSFERASES AND GENERAL ENZYMATIC METHODS FOR THE SYNTHESIS OF NATURAL AND "UNNATURAL" UDP- AND TDP-NUCLEOTIDE SUGARS
  申请人：THORSON Jon

  公开号：US20070178487A1

  公开（公告）日：2007-08-02

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified E p or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了突变核苷酸转移酶，例如Ep，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或改性的Epor或其他核苷酸转移酶合成所需核苷酸糖的方法；以及通过本方法合成的核苷酸糖。本发明还提供了新的糖基磷酸酯，以及制备它们的方法。
• Medium for detecting and differentiating vancomycin-resistant enterococci
  申请人：OXOID LIMITED

  公开号：EP2186906A2

  公开（公告）日：2010-05-19

  A medium for the growth of vancomycin-resistant Enterococci comprising:- (i) a nutrient medium with an energy source effective to support growth and reproduction of vancomycin-resistant Enterococci; (ii) an effective amount of one or more selective agents to inhibit the growth of microorganisms other than vancomycin-resistant Enterococci; (iii) a Krebs cycle intermediate.

  一种用于耐万古霉素肠球菌生长的培养基，包括 (i) 营养培养基，其中含有有效支持耐万古霉素肠球菌生长和繁殖的能量源； (ii) 一种或多种抑制耐万古霉素肠球菌以外的微生物生长的有效量的选择性制剂； (iii) 克雷布斯循环中间体。
• METABOLICALLY ENGINEERED ORGANISMS FOR THE PRODUCTION OF ADDED VALUE BIO-PRODUCTS
  申请人：Universiteit Gent

  公开号：EP3235907A1

  公开（公告）日：2017-10-25

  The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value bio-products such as specialty saccharide, activated saccharide, nucleoside, glycoside, glycolipid or glycoprotein. More specifically, the present invention relates to host cells that are metabolically engineered so that they can produce said valuable specialty products in large quantities and at a high rate by bypassing classical technical problems that occur in biocatalytical or fermentative production processes.

  本发明涉及用于生产高附加值生物产品（如特种糖、活性糖、核苷、糖苷、糖脂或糖蛋白）的基因工程生物，特别是微生物，如细菌和酵母。更具体地说，本发明涉及经过代谢工程改造的宿主细胞，这些宿主细胞可以绕过生物催化或发酵生产过程中出现的传统技术问题，大量、高速地生产上述有价值的特种产品。