3,6-dithiaoctan-1,8-dithiol | 25423-55-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: 3,6-dithiaoctan-1,8-dithiol
• 英文别名: 3,6-dithiaoctane-1,8-dithiol；2-[2-(2-sulfanylethylsulfanyl)ethylsulfanyl]ethanethiol
• CAS: 25423-55-6
• 化学式: C₆H₁₄S₄
• 分子量: 214.441
• InChiKey: MXTOXODEXBYZFX-UHFFFAOYSA-N

物化性质

• 熔点：
  15-17 °C
• 沸点：
  168-172 °C(Press: 10 Torr)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,6-dithiaoctan-1,8-dithiol 在 正丁基锂 、 caesium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 生成
  参考文献：
  名称：

  Screening Mercury Levels in Fish with a Selective Fluorescent Chemosensor

  摘要：

  Societal concerns over toxic mercury accumulation in humans from fish and other dietary and environmental sources provide motivation to develop new tools and tactics for mercury detection in a wide range of laboratory and field settings. Here we report the synthesis, properties, and application of a selective and sensitive small-molecule chemosensor for fluorescence screening of mercury levels in fish. Mercuryfluor-1 (MF1) is a water-soluble, fluorescein-based reagent that features excellent selectivity for Hg2+ over competing analytes and the largest turn-on fluorescence response to date (>170-fold increase) for reporting this heavy metal ion in aqueous solution. Combining this chemoselective Hg2+ probe with a microwave digestion protocol provides a facile method for assaying mercury levels in fish samples with mercury concentrations spanning 0.1 to 8 ppm, a range well matched with the United States Environmental Protection Agency (U.S. EPA) standard for the maximum safe level of mercury in edible fish (0.55 ppm).

  DOI：

  10.1021/ja0557987
• 作为产物：
  描述：

  1,2-二乙烷 在 lithium aluminium tetrahydride 、 Cs(SCOCH₃)2 作用下， 生成 3,6-dithiaoctan-1,8-dithiol
  参考文献：
  名称：

  Synthesis of the macrocyclic thiocrown ethers 1,4,7,10,13,16,19-heptathiaheneicosane (21-S-7) and 1,4,7,10,13,16,19,22-octathiatetraeicosane (24-S-8)

  摘要：

  The synthesis and characterization of the two macrocyclic sulfides, 1,4,7,10,13,16,19-heptathiaheneicosane (21-S-7) and 1,4,7,10,13,16,19,22-octathiatetraeicosane (24-S-8), are described starting from different combinations of dithiols and dichlorides of differing chain lengths. Cs2CO3 is used for the cyclizations.

  DOI：

  10.1016/s0040-4020(01)85071-7

文献信息

• Silver Ion Selective Extraction with Dithiaza-, Tetrathiaza-, and Tetrathiadiazacrown Ether Derivatives
  作者：Hidefumi Sakamoto、Junichi Ishikawa、Makoto Otomo

  DOI：10.1246/bcsj.68.2831

  日期：1995.10

  Dithiazacrown, tetrathiazacrown, and two tetrathiadiazacrown ether derivatives, bearing a phenyl group on each nitrogen atom at the periphery, were synthesized, and the solvent extractions of some transition metal ions with these compounds were carried out using an H2O–1,2-dichloroethane system. All of the thiazacrown compounds employed exhibited Ag+ selectivity, and formed 1 : 1 : 1 complexes of Ag+ : ligand : laurate ion as a counter anion to be extracted into a 1,2-dichloroethane solution. The extractabilities (extraction constants, Kex) for Ag+ decreased in the order: 7,16-diphenyltetrathia-7,16-diaza-18-crown-6 (3) (log Kex = 1.18 ± 0.13) > 13-phenyltetrathia-13-aza-15-crown-5 (2) (0.75 ± 0.09) > 7-phenyldithia-7-aza-9-crown-3 (1) (−0.47 ± 0.06) > 13,16-diphenyltetrathia-13,16-diaza-18-crown-6 (4) (−0.62 ± 0.16).

  合成了二硫氮杂冠醚、四硫氮杂冠醚以及两种四硫二氮杂冠醚衍生物，这些化合物在每一个氮原子外围都带有一个苯基。使用水-1,2-二氯乙烷系统，研究了这些化合物对某些过渡金属离子的萃取。所有这些硫氮杂冠醚化合物都对银离子有选择性，并且形成了银离子：配体：月桂酸离子1:1:1的络合物，作为被萃取到1,2-二氯乙烷溶液中的反离子。银离子的萃取能力（萃取常数，Kex）按以下顺序递减：7,16-二苯基四硫-7,16-二氮杂-18-冠-6（3）（log Kex = 1.18 ± 0.13）> 13-苯基四硫-13-氮杂-15-冠-5（2）（0.75 ± 0.09）> 7-苯基二硫-7-氮杂-9-冠-3（1）（−0.47 ± 0.06）> 13,16-二苯基四硫-13,16-二氮杂-18-冠-6（4）（−0.62 ± 0.16）。
• Synthesis and Metal-Ion Binding Properties of Monoazathiacrown Ethers
  作者：Mutsuo Tanaka、Makoto Nakamura、Tomokazu Ikeda、Kiyomi Ikeda、Hisanori Ando、Yasuhiko Shibutani、Setsuko Yajima、Keiichi Kimura

  DOI：10.1021/jo015709i

  日期：2001.10.1

  procedures for monoazathiacrown ethers were explored, and monoazatrithia-12-crown-4, monoazatetrathia-15-crown-5, and monoazapentathia-18-crown-6 were obtained in moderate yields by the reaction of bis(2-chloroethyl)amine with the appropriate dithiols in the presence of lithium hydroxide in THF. To evaluate metal-ion binding properties of the monoazathiacrown ethers by solvent extraction, lipophilic dodecyl

  探索了单氮杂蒽酮醚的合成方法，并通过双（2-氯乙基）胺与双（2-氯乙基）胺的反应以中等收率获得了单氮杂trithia-12-crown-4，单氮杂异硫磷-15-crown-5和单氮杂戊硫杂-18-18-crown-6。在氢氧化锂存在下，在THF中加入合适的二硫醇。为了评估通过溶剂萃取的单氮杂冠氮醚的金属离子结合性能，将亲脂性十二烷基和十二烷酰基结合到单氮杂冠氮醚上。溶剂萃取实验表明，单氮杂冠冕醚具有Ag（+）和Hg（2+）选择性，并且Ag（+）和Hg（2+）之间的相对选择性取决于它们的氮原子特性和反映各自的硫原子数氮和硫原子对Hg（2+）和Ag（+）的亲和力
• Synthesis and alkyne coordination chemistry of thiacycloalkynes
  作者：Francesca M. Kerton、G.Farouq Mohmand、Adrian Tersteegen、Markus Thiel、Michael J. Went

  DOI：10.1016/s0022-328x(96)06183-9

  日期：1996.7

  respectively. The X-ray crystal structures of 1,4-dithiacyclooct-6-yne and 1,6-dithiacyclodec-8-yne have been determined. Selective coordination of the alkyne functionality is demonstrated by the reaction of 1,4,7-tetrathiacyclotetradec-12-yne with [Co2(CO) 8] to afford a monoalkyne hexacarbonyldicobalt complex and by the reaction of 1,4,7-trithiacycloundec-9-yne with [Mo(CO)2(S2CNMe2)2] to afford a bisalkyn

  1,4-二氯丁-2-炔与HS（CH 2）n SH（n = 2–5）或HS（CH 2 CH 2 S）n H（n = 2–3）或HSCH 2 CH（ OH）CH 2当1：1的产物为9元，10元或11元环时，在工业稀释的甲基化酒精中，使用KOH作为去质子化剂的SH可以显着高收率地产生噻吩炔。1,5-二硫代环酮-7-炔，1,5-二硫代环酮-7-炔-3-醇，1,6-二硫代环癸-8-炔，1,7-二硫代环十一-炔，1,4,7-分别以75％，81％，79％，85％，100％和95％的产率制备三硫代环十一醛-9-炔和1,7-二硫代-4-氧杂-环十一环-9-炔。已经确定了1，4-二硫代环辛-6-yne和1，6-二硫代环癸-8-yne的X射线晶体结构。1,4,7-四硫代环四癸-12-炔与[Co 2（CO）8]，得到单炔六羰基二钴配合物，并通过1,4,7-三硫代环十一碳烯9-炔与[Mo（CO）2（S 2 CNMe
• Process for the preparation of 2-mercaptoalkyl-sulphides and
  申请人：Agfa-Gevaert Aktiengesellschaft

  公开号：US04355185A1

  公开（公告）日：1982-10-19

  2-Mercaptoalkylsulphides and 2-mercaptoalkylethers are obtained by the hydrazinolysis of 3-thiaalkylisothiuronium salts and 3-oxaalkylisothiuronium salts.

  2-巯基烷基硫醚和2-巯基烷基醚是通过对3-硫代烷基异硫脲盐和3-氧代烷基异硫脲盐进行肼解得到的。
• Internal release agent, composition including internal release agent, and process for producing a plastic lens using same composition
  申请人：MITSUI CHEMICALS, INC.

  公开号：US10239239B2

  公开（公告）日：2019-03-26

  An internal release agent includes at least one phosphodiester represented by the following general formula (1). In the formula, R1 and R2 independently represent a hydrocarbon group having 1 to 30 carbon atoms, which is optionally substituted with at least one hydroxyl group, and R3 represents an alkylene group having 2 to 4 carbon atoms. A plurality of R3's may be the same as or different from each other. M represents a hydrogen atom, an ammonium ion, an alkali metal ion, or a monovalent/divalent alkali earth metal ion, and n is an integer of 1 to 60.

  内部释放剂至少包括一个由以下一般式（1）表示的磷酸二酯。在该式中，R1和R2分别表示具有1至30个碳原子的烃基，该烃基可以选择性地取代至少一个羟基，而R3表示具有2至4个碳原子的烷基基团。多个R3可以相同或者彼此不同。M代表氢原子、铵离子、碱金属离子或者一价/二价碱土金属离子，n为1至60的整数。