二-正-丁基-乙胺 | 4458-33-7

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 二-正-丁基-乙胺
• 英文名称: dibutylethylamine
• 英文别名: di-n-butylethylamine；N-butyl-N-ethylbutan-1-amine
• CAS: 4458-33-7
• 化学式: C₁₀H₂₃N
• mdl: MFCD00051919
• 分子量: 157.299
• InChiKey: BBDGYADAMYMJNO-UHFFFAOYSA-N

物化性质

• 沸点：
  181-182 °C(lit.)
• 密度：
  0.757 g/mL at 25 °C(lit.)
• 闪点：
  124 °F
• 保留指数：
  1014;1004.6
• 稳定性/保质期：

  如果遵照规格使用和储存，则不会分解，未有已知危险发生。

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  C
• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• WGK Germany：
  3
• 海关编码：
  2921199090
• 危险品运输编号：
  UN 2734 8/PG 2
• 储存条件：
  存储条件：2至-8°C，应密封存放在阴凉干燥处。

SDS

---

Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product name : Di-n-butylethylamine

---

Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
According to Regulation (EC) No1272/2008
Flammable liquids (Category 3)
Skin corrosion (Category 1B)
According to European Directive 67/548/EEC as amended.
Flammable. Causes burns.
Label elements
Pictogram
Signal word Danger
Hazard statement(s)
H226 Flammable liquid and vapour.
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Hazard symbol(s)
C Corrosive
R-phrase(s)
R10 Flammable.
R34 Causes burns.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Other hazards - none

---

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Formula : C10H23N
Molecular Weight : 157,3 g/mol
CAS-No. EC-No. Index-No. Classification Concentration
N-Ethyldibutylamine
4458-33-7 224-711-2 - Flam. Liq. 3; Skin Corr. 1B; -
H226, H314
C, R10 - R34
For the full text of the H-Statements mentioned in this Section, see Section 16.

---

Section 4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water.
Consult a physician.

---

Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires,
apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray;
solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

---

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place
in container for disposal according to local regulations (see section 13).

---

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic
charge.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C

---

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with
multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to
engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves
after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Eye protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of
protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.

---

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form liquid
Colour colourless
Safety data
pH no data available
Melting point no data available
Boiling point 181 - 182 °C - lit.
Flash point 51 °C - closed cup
Ignition temperature no data available
Lower explosion limit no data available
Upper explosion limit no data available
Density 0,757 g/cm3 at 25 °C
Water solubility no data available

---

Section 10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
Heat, flames and sparks.
Materials to avoid
Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx)

---

Section 11. TOXICOLOGICAL INFORMATION
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the
mucous membranes and upper respiratory tract.
Ingestion May be harmful if swallowed. Causes burns.
Skin
May be harmful if absorbed through skin. Causes skin burns.
Eyes Causes eye burns.
Signs and Symptoms of Exposure
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi,
pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath,
Headache, Nausea
Additional Information
RTECS: Not available

---

Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available

---

Section 13. DISPOSAL CONSIDERATIONS
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as
this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

---

Section 14. TRANSPORT INFORMATION
ADR/RID
UN-Number: 2734 Class: 8 (3) Packing group: II
Proper shipping name: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (N-Ethyldibutylamine)
IMDG
UN-Number: 2734 Class: 8 (3) Packing group: II EMS-No: F-E, S-C
Proper shipping name: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. (N-Ethyldibutylamine)
Marine pollutant: No
IATA
UN-Number: 2734 Class: 8 (3) Packing group: II
Proper shipping name: Amines, liquid, corrosive, flammable, n.o.s. (N-Ethyldibutylamine)

---

Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

---

Section 16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
Flam. Liq. Flammable liquids
H226 Flammable liquid and vapour.
H314 Causes severe skin burns and eye damage.
Skin Corr. Skin corrosion
C Corrosive
R10 Flammable.
R34 Causes burns.
Further information
Copyright 2010 Co. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee
of the properties of the product. Co., shall not be held liable for any damage resulting from
handling or from contact with the above product. See reverse side of invoice or packing slip for additional
terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  二-正-丁基-乙胺 、 氯甲酸乙酯 以 苯 为溶剂， 生成 N-(Butyl-ethyl)-carbaminsaeureethylester
  参考文献：
  名称：

  On the cleavage of tertiary amines with ethyl chloroformate.

  摘要：

  在回流苯中，研究了47种叔胺与ClCO2Et的反应，以观察各种N-取代基相对于断裂的相对活泼性。芳香胺不与ClCO2Et反应，而脂肪和脂环胺断裂生成氨基甲酸酯（或多肽）；导致R-N断裂的倾向为：苄基>烯丙基>甲基>乙基>其他烷基。研究发现，叔胺与ClCO2Et的反应受溶剂极性、反应温度和N-取代基的显著影响。

  DOI：

  10.1248/cpb.24.342
• 作为产物：
  描述：

  生成 二-正-丁基-乙胺
  参考文献：
  名称：

  Tumor inhibitors. XLIII. Solapalmitine and solapalmitenine, two novel alkaloid tumor inhibitors from Solanum tripartitum

  摘要：

  DOI：

  10.1021/jo01264a031
• 作为试剂：
  描述：

  3-羟基四氢吡喃 、 42-O-(trifluoromethylsulfonyl)rapamycin 在 二-正-丁基-乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 60.0h， 生成 42-O-(tetrahydropyran-3-yl)rapamycin
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARATION OF NOVEL 42-0-(HETEROALKOXYALKYL) RAPAMYCIN COMPOUNDS WITH ANTI-PROLIFERATIVE PROPERTIES"
  [FR] PROCÉDÉ DE PRÉPARATION DE NOUVEAUX COMPOSÉS DE 42-O-(HÉTÉROALCOXYALKYL)RAPAMYCINE AYANT DES PROPRIÉTÉS ANTIPROLIFÉRATIVES

  摘要：

  本发明公开了一种新型的42-0-(杂代烷氧基烷基) 霉素化合物，其化学式为（1），以及其制备方法。这些化合物在治疗高增殖性血管疾病，如再狭窄和动脉粥样硬化方面具有用途。其中，R代表选自四氢呋喃-3-醇、氧杂环戊烷-3-醇、四氢吡喃-3-醇、四氢-4-甲基呋喃-3-醇、四氢-2,5,5-三甲基呋喃-3-醇、四氢-2,5-二乙基-2-甲基呋喃-3-醇、四氢-6-甲氧基-2-甲基-2H-吡喃-3-醇和四氢-2,2-二甲基-6-苯基-2H-吡喃-3-醇的3、4和5元杂代3-羟基烷氧基烷基化合物。

  公开号：

  WO2012017449A1

文献信息

• [EN] SOLVENTS<br/>[FR] SOLVANTS
  申请人：BIONIQS LTD

  公开号：WO2009034329A1

  公开（公告）日：2009-03-19

  There is described the use of a protic ionic liquid comprising a trialkylammonium salt as a solvent.

  这里描述了一种包含三烷基铵盐的质子离子液体作为溶剂的使用。
• Salt suitable for an acid generator and a chemically amplified resist composition containing the same
  申请人：Harada Yukako

  公开号：US20070078269A1

  公开（公告）日：2007-04-05

  The present invention provides a salt of the formula (I): wherein ring Y represents monocyclic or polycyclic hydrocarbon group having 3 to 30 carbon atoms, in which one —CH 2 — group is substituted with —COO— group, and at least one hydrogen atom in the monocyclic or polycyclic hydrocarbon group may optionally be substituted with alkyl group having 1 to 6 carbon atom, alkoxy group having 1 to 6 carbon atom, perfluoroalkyl group having 1 to 4 carbon atoms, hydroxyalkyl group having 1 to 6 carbon atoms, hydroxyl group or cyano group; Q 1 and Q 2 each independently represent fluorine atom or perfluoroalkyl group having 1 to 6 carbon atoms; A + represents organic counter ion; and n shows an integer of 0 to 12. The present invention also provides a chemically amplified resist composition comprising the salt of the formula (I).

  本发明提供了一种具有公式(I)的盐： 其中环Y代表具有3至30个碳原子的单环或多元环烃基团，其中一个—CH2—基团被—COO—基团取代，并且单环或多元环烃基团中的至少一个氢原子可以可选地被具有1至6个碳原子的烷基取代，具有1至6个碳原子的烷氧基，具有1至4个碳原子的全氟烷基，具有1至6个碳原子的羟基烷基，羟基或腈基；Q1和Q2各自独立地代表氟原子或具有1至6个碳原子的全氟烷基；A+代表有机反离子；n表示0至12的整数。 本发明还提供了一种含有公式(I)盐的化学放大抗蚀剂组合物。
• SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
  申请人：ICHIKAWA Koji

  公开号：US20100304293A1

  公开（公告）日：2010-12-02

  A salt represented by the formula (a): wherein Q 1 and Q 2 each independently represent a fluorine atom etc., X 1 represents a single bond etc., X 2 represents a single bond etc., Y 1 represents a C3-C6 alicyclic hydrocarbon group etc., with the proviso that —X 2 —Y 1 group has one or more fluorine atoms, and Z + represents an organic counter cation, and a photoresist composition comprising the salt represented by the formula (a) and a resin comprising a structural unit having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solution by the action of an acid.

  由公式(a)表示的盐：其中Q1和Q2各自独立代表氟原子等，X1代表单键等，X2代表单键等，Y1代表C3-C6的脂环烃基等，但条件是—X2—Y1基团具有一个或多个氟原子，以及Z+代表有机反离子，以及包含由公式(a)表示的盐的光阻剂组合物和包含具有酸不稳定的基团并且在水性碱液中不溶或微溶于但在酸性作用下水性碱液中变得可溶的树脂的结构单元。
• SALT AND PROCESS FOR PRODUCING ACID GENERATOR
  申请人：YOSHIDA Isao

  公开号：US20110201823A1

  公开（公告）日：2011-08-18

  A salt represented by the formula (I0): wherein Q 1 and Q 2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L 1 represents a divalent C1-C17 hydrocarbon group in which one or more —CH 2 — can be replaced by —O— or —CO—, m represents 1 or 2, and Z m+ represents m-valent organic or inorganic cation.

  根据您提供的化学公式(I0)，其翻译成中文为： 其中Q1和Q2各自独立代表一个氟原子或一个C1-C6全氟烷基团，L1代表一个二价的C1-C17碳氢化合物基团，在该基团中，一个或多个—CH2—可以被—O—或—CO—所替换，m代表1或2，而Zm+代表m价有机或无机阳离子。
• [EN] ANTIMICROBIAL ALPHA-HELICAL CATIONIC POLYPEPTIDES<br/>[FR] POLYPEPTIDES CATIONIQUES ALPHA-HÉLICOÏDAUX ANTIMICROBIENS
  申请人：UNIV ILLINOIS

  公开号：WO2016210442A1

  公开（公告）日：2016-12-29

  The invention provides antimicrobial polypeptides (AMPs) with high radial amphiphilicity. Unlike typical AMPs characterized by facial amphiphilicity or biomimetic antimicrobial polymers with randomly distributed charged and hydrophobic groups, these new AMPs are homo-polypeptides with radially amphiphilic structure. They adopt a stable ?-helical conformation with a hydrophobic helical core and a charged exterior shell, formed by flexible hydrophobic side chains with terminal charge group. The radially amphiphilic polypeptides offer several advantages over conventional AMPs with regard to stability against protease and simplicity of design. They also exhibit high antibacterial activity against both Gram-negative and Gram-positive bacteria and low hemolytic activity. The AMPs thus provide a general platform for treating drug-resistant bacterial infections.

  该发明提供了具有高径向亲疏水性的抗菌多肽（AMPs）。与典型的具有表面亲疏水性的AMPs或具有随机分布带电和疏水基团的仿生抗菌聚合物不同，这些新的AMPs是具有径向亲疏水结构的同源多肽。它们采用稳定的α-螺旋构象，具有疏水螺旋核心和带电外壳，由具有末端带电基团的柔性疏水侧链形成。径向亲疏水多肽相对于传统AMPs具有多个优势，包括对蛋白酶的稳定性和设计的简单性。它们还表现出对革兰氏阴性和革兰氏阳性细菌的高抗菌活性和低溶血活性。因此，这些AMPs为治疗耐药细菌感染提供了一个通用平台。

表征谱图