马来酸倍他司汀 | 133206-34-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 马来酸倍他司汀
• 英文名称: betahistine maleate
• 英文别名: (Z)-but-2-enedioic acid;N-methyl-2-pyridin-2-ylethanamine
• CAS: 133206-34-5
• 化学式: C₄H₄O₄*C₈H₁₂N₂
• 分子量: 252.27
• InChiKey: JLPICNMNXPSXMA-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.5
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [2-(2-pyridyl)ethyl]-methylamine salts
  申请人：PRODOTTI FORMENTI S.r.l.

  公开号：EP0397025A1

  公开（公告）日：1990-11-14

  [2-(2-Pyridyl)ethyl]-methylamine (betahistine) salts with polycarboxylic acids such as fumaric, succinic, maleic, citric, tartaric, malonic acids, have improved physico-chemical, toxicologic and pharmacokine­tic characteristics so as to be valuable as medicaments.

  与富马酸、琥珀酸、马来酸、柠檬酸、酒石酸、丙二酸等聚羧酸的[2-(2-吡啶基)乙基]甲胺（倍他司汀）盐具有更好的物理化学、毒理学和药代动力学特性，因此具有药物价值。
• Pharmaceutical composition comprising betahistine
  申请人：Otolanum AG

  公开号：US10456386B2

  公开（公告）日：2019-10-29

  The present disclosure relates to a pharmaceutical composition comprising as active substance betahistine or a pharmaceutically acceptable salt thereof, for use in the treatment of otological or neurological disorders in a human subject by intranasal application.

  本公开涉及一种药物组合物，其活性物质包括倍他司汀或其药学上可接受的盐，用于通过鼻内施用治疗人的耳科或神经系统疾病。
• INTRANASAL COMPOSITION COMPRISING BETAHISTINE
  申请人：Otolanum AG

  公开号：EP3474850A1

  公开（公告）日：2019-05-01
• PHARMACEUTICAL COMPOSITION COMPRISING BETAHISTINE
  申请人：Otolanum AG

  公开号：US20180214432A1

  公开（公告）日：2018-08-02

  The present disclosure relates to a pharmaceutical composition comprising as active substance betahistine or a pharmaceutically acceptable salt thereof, for use in the treatment of otological or neurological disorders in a human subject by intranasal application.
• [EN] WATER DISPERSIBLE FORMULATION<br/>[FR] FORMULATION HYDRODISPERSABLE
  申请人：BILGIC MAHMUT

  公开号：WO2011139250A2

  公开（公告）日：2011-11-10

  The present invention relates to new water dispersible pharmaceutical formulations comprising betahistine as the active agent.