2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-(4-methoxyphenyl)-3,3-dimethyl-3,4,5,12-tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-one | 1591873-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-(4-methoxyphenyl)-3,3-dimethyl-3,4,5,12-tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-one
• 英文别名: 11-(4-hydroxy-2-oxochromen-3-yl)-6-(4-methoxyphenyl)-8,8-dimethyl-9,11-dihydro-7H-quinolino[2,3-b]quinolin-10-one
• CAS: 1591873-20-9
• 化学式: C₃₄H₂₈N₂O₅
• 分子量: 544.607
• InChiKey: JJCCLRVUXMCZBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  41
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 2-氯-3-喹啉甲醛 、 3-[(4-甲氧苯基)氨基]-5,5-二甲基-1-环己-2-烯酮 在 L-脯氨酸 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以80%的产率得到2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-(4-methoxyphenyl)-3,3-dimethyl-3,4,5,12-tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-one
  参考文献：
  名称：

  Efficient Synthesis of Functionalized Benzo[b][1,8]naphthyridine Derivatives via Three-Component Reaction Catalyzed by l-Proline

  摘要：

  A facile and efficient one-pot procedure for the preparation of functionalized benzo[b][1,8]naphthyridine derivatives by three-component reaction of 2-chloroquinoline-3-carbaldehyde, 1,3-dicarbonyl compounds, and enaminones catalyzed by l-proline is described. This new protocol has the advantages of environmental friendliness, good yields, and convenient operation.

  DOI：

  10.1021/co4001524

文献信息

• Efficient Synthesis of Functionalized Benzo[<i>b</i>][1,8]naphthyridine Derivatives via Three-Component Reaction Catalyzed by <scp>l</scp>-Proline
  作者：Lei Fu、Wei Lin、Ming-Hua Hu、Xue-Cheng Liu、Zhi-Bin Huang、Da-Qing Shi

  DOI：10.1021/co4001524

  日期：2014.5.12

  A facile and efficient one-pot procedure for the preparation of functionalized benzo[b][1,8]naphthyridine derivatives by three-component reaction of 2-chloroquinoline-3-carbaldehyde, 1,3-dicarbonyl compounds, and enaminones catalyzed by l-proline is described. This new protocol has the advantages of environmental friendliness, good yields, and convenient operation.