3-(2-bromophenoxy)pyridine | 18085-59-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-bromophenoxy)pyridine
• 英文别名: 3-(2-Bromphenoxy)-pyridin
• CAS: 18085-59-1
• 化学式: C₁₁H₈BrNO
• 分子量: 250.095
• InChiKey: ASQFHYZZWANCJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-bromophenoxy)pyridine 、 哌嗪 、 生成 1-[2-(Pyridin-3-yloxy)-phenyl]-piperazine
  参考文献：
  名称：

  Melanocortin receptor agonists

  摘要：

  本发明涉及公式（I）的黑色素皮质素受体激动剂，其在肥胖症、糖尿病和男性和/或女性性功能障碍的治疗中有用。

  公开号：

  US20040092507A1
• 作为产物：
  描述：

  3-(2-nitrophenoxy)pyridine 在 氢溴酸 、 铁粉 、 铜 、 溶剂黄146 、 sodium nitrite 作用下， 反应 1.5h， 生成 3-(2-bromophenoxy)pyridine
  参考文献：
  名称：

  Cognition-activating properties of 3-(aryloxy)pyridines

  摘要：

  A series of 3-(aryloxy)pyridines was found to possess activity in enhancing retention for passive avoidance learning in mice. This test was used to select compounds with potential therapeutic properties for the treatment of cognitive disorders. Reference drugs that gave positive results in this procedure included d-amphetamine, magnesium pemoline, methyl phenidate, picrotoxin, phenytoin, and ethosuximide. All active compounds gave inverted U-shaped dose-response curves. The most active compounds of the 3-(aryloxy)pyridines included 3-phenoxypyridine (1), 3-(2-fluorophenoxy)pyridine (2), 3-(4-fluorophenoxy)pyridine (4), 3,3'-oxybis(pyridine) (23), and 3,3'-oxybis(pyridine) 1-oxide (24). 3-Phenoxypyridine (1) was clearly superior to all of the analogues tested in terms of the level of retention, grammometric potency, and the breadth of its inverted U-shaped dose-response curve. It was given the designation of CI-844 and after a detailed study of its pharmacological profile was submitted for preclinical toxicology.

  DOI：

  10.1021/jm00135a020

文献信息

• BUTLER D. E.; POSCHEL B. P. H.; MARRIOTT J. G., J. MED. CHEM., 1981, 24, NO 3, 346-350
  作者：BUTLER D. E.、 POSCHEL B. P. H.、 MARRIOTT J. G.

  DOI：——

  日期：——
• PIPERAZINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1368340A1

  公开（公告）日：2003-12-10
• US7291619B2
  申请人：——

  公开号：US7291619B2

  公开（公告）日：2007-11-06
• [EN] MELANOCORTIN RECEPTOR AGONISTS<br/>[FR] DERIVES DE PIPERAZINE AGONISTES DU RECEPTEUR DE LA MELANOCORTINE
  申请人：LILLY CO ELI

  公开号：WO2002059108A1

  公开（公告）日：2002-08-01

  The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.