O-乙基-N-[芴甲氧羰基]-L-酪氨酸 | 119894-20-1

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: O-乙基-N-[芴甲氧羰基]-L-酪氨酸
• 英文名称: 4-ethoxy-N-[fluorenylmethoxycarbonyl]-L-phenylalanine
• 英文别名: Fmoc-O-ethyl-L-tyrosine；(2S)-3-(4-ethoxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
• CAS: 119894-20-1
• 化学式: C₂₆H₂₅NO₅
• 分子量: 431.488
• InChiKey: XUKUVROJKPSLLU-DEOSSOPVSA-N

物化性质

• 沸点：
  654.3±55.0 °C(Predicted)
• 密度：
  1.254±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• [EN] REDOX DEHYDRATION COUPLING CATALYSTS AND METHODS RELATED THERETO<br/>[FR] CATALYSEURS DE COUPLAGE DE DÉSHYDRATATION RÉDOX ET PROCÉDÉS ASSOCIÉS À CEUX-CI
  申请人：UNIV EMORY

  公开号：WO2017070157A1

  公开（公告）日：2017-04-27

  This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, diselenide compound, ditelluride compound or tellurium containing heterocycle. Catalytic molecules disclosed herein are useful as catalysts in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.

  这份披露涉及使用催化分子的合成偶联方法。在某些实施例中，这些催化分子包括杂环硫酰胺、S-酰基硫代水杨酰胺、二硫化物、含硒杂环、二硒化合物、二碲化合物或含碲杂环。本文披露的催化分子可用作催化剂，用于将含羟基化合物转化为酰胺、酯、酮和其他碳到杂原子或碳到碳的转化过程中。
• [EN] HETEROCYCLIC COUPLING CATALYSTS AND METHODS RELATED THERETO<br/>[FR] CATALYSEURS DE COUPLAGE HÉTÉROCYCLIQUE ET PROCÉDÉS ASSOCIÉS À CEUX-CI
  申请人：UNIV EMORY

  公开号：WO2015054337A1

  公开（公告）日：2015-04-16

  This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon, such as sulfur, such as a sufur amide nitrogen bond, typically in a heterocycle, such as substituted benzoisothiazolones and derivatives thereof, as a catalyst in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.

  本披露涉及使用催化分子的合成偶联方法，其中该催化分子包含两个键合原子，其中一个原子是酰胺氮，第二个原子不是氮或碳，例如硫，例如硫酰胺氮键，通常在杂环中，例如取代苯并异噻唑酮及其衍生物，用作催化剂将含羟基的化合物转化为酰胺，酯，酮和其他碳到杂原子或碳到碳的转化。
• MUCIN HYPERSECRETION INHIBITORS AND METHODS OF USE
  申请人：Biomarck Pharmaceuticals, Ltd.

  公开号：EP2399599A2

  公开（公告）日：2011-12-28

  Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 23 contiguous amino acids of a reference sequence PEPTIDE 1; (b) an amino acid sequence substantially identical to the sequence defined in (a); and (c) a variant of the amino acid sequence defined in (a). Also provided is a non-myristoylated MANS peptide. Various methods of using the peptides are also provided.

  所提供的多肽由少于 24 个氨基酸组成。这些多肽的氨基酸序列选自以下一组：(a)具有 4 至 23 个连续氨基酸的参考序列 PEPTIDE 1 的氨基酸序列；(b)与(a)中定义的序列基本相同的氨基酸序列；以及(c)(a)中定义的氨基酸序列的变体。还提供了一种非肉豆蔻酰化的 MANS 肽。还提供了使用这些肽的各种方法。
• Heterocyclic Coupling Catalysts and Methods Related Thereto
  申请人：EMORY UNIVERSITY

  公开号：US20160243534A1

  公开（公告）日：2016-08-25

  This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon, such as sulfur, such as a sufur amide nitrogen bond, typically in a heterocycle, such as substituted benzoisothiazolones and derivatives thereof, as a catalyst in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.
• Redox Dehydration Coupling Catalysts and Methods Related Thereto
  申请人：Emory University

  公开号：US20180318818A1

  公开（公告）日：2018-11-08

  This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, diselenide compound, ditelluride compound or tellurium containing heterocycle. Catalytic molecules disclosed herein are useful as catalysts in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.