Holmium(3+) acetate | 25519-09-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物的盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Holmium(3+) acetate
• 英文别名: holmium(3+);triacetate
• CAS: 25519-09-9
• 化学式: C6H9HoO6
• 分子量: 342.06
• InChiKey: HWQRVFRWLQGBFV-UHFFFAOYSA-K

物化性质

• 溶解度：
  溶于H2O
• 稳定性/保质期：

  与1,10-菲啰啉反应（参见文献［157］），生成络合物，在261～263℃下分解。

计算性质

• 辛醇/水分配系数(LogP)：
  -3.73
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

毒理性

• 副作用

纤维原性 - 引发组织损伤和纤维化（疤痕形成）。

Fibrogenic - Inducing tissue injury and fibrosis (scarring).

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• TSCA：
  Yes
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38

SDS

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Section 1: Product Identification
Chemical Name: Holmium (III) acetate monohydrate (99.9%-Ho) (REO)
CAS Registry Number: 25519-09-9
Formula: Ho(OOCCH3)3.H2O
EINECS Number: none
Chemical Family: metal acetate salt
Synonym: Acetic acid, holmium(+3) salt, hydrate

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 25519-09-9 100% no data no data

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Section 3: Hazards Identification
Emergency Overview: Irritating to skin, eyes and respiratory tract.
Primary Routes of Exposure: Ingestion, Inhalation of dust.
Eye Contact: Causes slight to mild irritation of the eyes.
Skin Contact: Causes slight to mild irritation of the skin.
Inhalation: Irritating to the nose, mucous membranes and respiratory tract.
Ingestion: No information on the physiological effects of ingestion.
Acute Health Affects: Irritating to skin, eyes and respiratory tract.
Chronic Health Affects: No information available on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Ingestion: Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious).

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SECTION 5: Fire Fighting Measures
Flash Point: not applicable
Autoignition Temperature: none
Explosion Limits: none
Extinguishing Medium: carbon dioxide, dry powder or foam
If involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure self-contained
Special Fire Fighting Procedures:
breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit toxic organic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Spill and Leak Procedures: Small spills can be mixed with vermiculite or sodium carbonate and swept up.

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SECTION 7: Handling and Storage
Handling and Storage: Store in a sealed container. Keep away from heat and moisture.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear appropriate chemical resistant gloves and protective clothing.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If in form of fine dust and ventilation is not available a respirator should be worn. The use of respirators
Respirator:
requires a Respirator Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: peach pwdr.
Molecular Weight: 342.07 (360.09)
Melting Point: no data
Boiling Point: no data
Vapor Pressure: not applicable
Specific Gravity: no data
Odor: none
Solubility in Water: soluble

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable solid
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: oxidizing agents
Decomposition Products: Carbon dioxide, carbon monoxide, organic vapors, and metal oxides and carbonates.

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

醋酸钬概述

醋酸钬的化学式为C₆H₉HoO₆，CAS号为312619-49-1，分子量为342.06200。研究表明，稀土元素可能会导致大白鼠肝脏和肺部脂质过氧化损伤，进而产生活性自由基，引起碱基损伤、DNA链断裂，并具有致突变作用。体外培养A549肺癌细胞的试验也证实了，受SOD活力抑制剂处理的细胞染色体畸变率明显增高，并表现出一定的毒性变化。当机体细胞产生SOD能力下降或内环境自由基浓度增大时，细胞膜及遗传物质可能受到不同程度的损伤。高剂量的稀土元素钬也可能具有致突变作用。

制备方法

一种醋酸钬晶体的制备方法包括以下步骤：

1. 将分析纯冰醋酸与去离子水按体积比1:0.5泵入反应釜中，搅拌均匀并加热至50℃。
2. 转动搅拌桨并将称量好的碳酸钬缓缓加入反应釜，碳酸钬的加入量与醋酸摩尔比为1：3.3。
3. 完全反应后，将液料加热至110℃-125℃停止加热，使反应釜内液料自然冷却结晶。
4. 当液料温度冷却至50℃以下时，搅拌桨停止搅拌，并排放到过滤箱中滤去液体。
5. 将滤去液体的反应物放入离心脱水机脱水25至30分钟。
6. 脱水后的反应物晾在无尘间自然蒸发直到醋酸钬晶体的稀土总量：45%≥醋酸钬的稀土总量（REO）≥33%。

生产方法

生产醋酸钬的过程如下：

1. 取氧化钬(Ⅲ) 10g 加至500mL 50% 醋酸溶液中，用砂浴加热，通常可完全溶解。若瓶底仍有少量未溶的氧化物，则需过滤成清液。
2. 将滤液置于75℃水浴上加热以蒸去大部分溶剂，冷却后滤集晶体。
3. 将晶体放入玻璃皿中，置于装有固体氢氧化钠和高氯酸镁的真空干燥器中抽真空进行干燥，得到水合醋酸钬(Ⅲ)。
4. 将水合物在真空中于150℃加热约24小时或至恒重，得到无水醋酸钬(Ⅲ)。