4-[2-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-1,1,2,2-tetrafluoroethyl]cyclohexan-1-one | 433719-72-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[2-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-1,1,2,2-tetrafluoroethyl]cyclohexan-1-one
• CAS: 433719-72-3
• 化学式: C₁₉H₂₈F₄O₃
• 分子量: 380.423
• InChiKey: TWRHCQNEDSEZKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-[2-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-1,1,2,2-tetrafluoroethyl]cyclohexan-1-one 在 palladium on activated charcoal 甲酸 、 potassium tert-butylate 、 氢气 作用下， 以 四氢呋喃 、 甲苯 为溶剂， -10.0~20.0 ℃ 、100.0 kPa 条件下， 反应 54.0h， 生成
  参考文献：
  名称：

  Liquid crystals with multiple fluorinated bridges in the mesogenic core structure

  摘要：

  A rational, building block oriented design approach gives rise to a new class of "super fluorinated" liquid crystals suitable for the newest generation of active matrix LCDs. These materials contain combinations of different fluorinated linking groups in their mesogenic core structure, resulting in a highly advantageous property profile including a broad nematic phase range, low rotational viscosity and high dielectric anisotropy. The large-scale synthesis of such complex materials became feasible only by some recent advances in the synthesis of alpha,alpha -difluoroether linkages. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00488-2
• 作为产物：
  描述：

  4-[1,1,2,2-Tetrafluoro-2-(4-hydroxycyclohexyl)ethyl]cyclohexan-1-ol 在 硫酸 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 、 环己烷 为溶剂， 反应 28.0h， 生成 4-[2-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yl)-1,1,2,2-tetrafluoroethyl]cyclohexan-1-one
  参考文献：
  名称：

  Liquid crystals with multiple fluorinated bridges in the mesogenic core structure

  摘要：

  A rational, building block oriented design approach gives rise to a new class of "super fluorinated" liquid crystals suitable for the newest generation of active matrix LCDs. These materials contain combinations of different fluorinated linking groups in their mesogenic core structure, resulting in a highly advantageous property profile including a broad nematic phase range, low rotational viscosity and high dielectric anisotropy. The large-scale synthesis of such complex materials became feasible only by some recent advances in the synthesis of alpha,alpha -difluoroether linkages. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00488-2

文献信息

• [EN] CHIRAL COMPOUNDS II<br/>[FR] COMPOSES CHIRAUX DE TYPE II
  申请人：MERCK PATENT GMBH

  公开号：WO2002006195A1

  公开（公告）日：2002-01-24

  The invention relates to chiral compounds of formula (I) R?1-X1-(A1-Z1)¿m-G-(Z2-A2)n-X2-R2, wherein R?1, R2, X1, X2, A1, A2, Z1, Z2¿, G, m and n have the meaning given in claim 1, to liquid crystalline mixtures comprising at least one chiral compound of formula (I), to chiral linear or crosslinked liquid crystalline polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formual (I), to the use of chiral compounds of formula (I) and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula (I).

  该发明涉及具有式(I)的手性化合物，其中R?1、R2、X1、X2、A1、A2、Z1、Z2、G、m和n的含义如权利要求1中所述，涉及至少包含一种式(I)手性化合物的液晶混合物，可通过聚合包含至少一种式(I)手性化合物的可聚合混合物获得手性线性或交联液晶聚合物，以及手性化合物的使用(I)和由此获得的混合物和聚合物在液晶显示器、主动和被动光学元件、粘合剂、具有各向异性机械性能的合成树脂、化妆品和药用组合物、诊断、液晶颜料、用于装饰和安全应用、非线性光学、光学信息存储或作为手性掺杂剂，并涉及包含至少一种式(I)手性化合物的混合物的液晶显示器。
• Liquid-crystalline compounds
  申请人：Merck GmbH

  公开号：US20030230737A1

  公开（公告）日：2003-12-18

  The invention relates to liquid-crystalline compounds of the formula I, 1 and to liquid-crystalline media comprising at least one compound of the formula I and to electro-optical displays containing such a liquid-crystalline medium.

  本发明涉及公式I中的液晶化合物，以及包含至少一种公式I化合物的液晶介质和包含这样液晶介质的电光显示器。
• 2,4'-SUBSTITUIERTE 6-CYCLOHEXYL-TRANS-DEKALINE
  申请人：Merck Patent GmbH

  公开号：EP1373175B1

  公开（公告）日：2009-07-08
• US7385067B2
  申请人：——

  公开号：US7385067B2

  公开（公告）日：2008-06-10
• Liquid crystals with multiple fluorinated bridges in the mesogenic core structure
  作者：Peer Kirsch、Florian Huber、Marc Lenges、Andreas Taugerbeck

  DOI：10.1016/s0022-1139(01)00488-2

  日期：2001.11

  A rational, building block oriented design approach gives rise to a new class of "super fluorinated" liquid crystals suitable for the newest generation of active matrix LCDs. These materials contain combinations of different fluorinated linking groups in their mesogenic core structure, resulting in a highly advantageous property profile including a broad nematic phase range, low rotational viscosity and high dielectric anisotropy. The large-scale synthesis of such complex materials became feasible only by some recent advances in the synthesis of alpha,alpha -difluoroether linkages. (C) 2001 Elsevier Science B.V. All rights reserved.