1β,2α,3β,11α-tetrahydroxyolean-12-ene | 252267-28-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1β,2α,3β,11α-tetrahydroxyolean-12-ene
• 英文别名: 1β,2α,11α-tetrahydroxy-olean-12-ene；(1S,2S,3R,4aS,6aR,6bS,8aR,12aR,14R,14aS,14bS)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-1,2,3,14-tetrol
• CAS: 252267-28-0
• 化学式: C₃₀H₅₀O₄
• 分子量: 474.725
• InChiKey: RLHPTCMHCBNJKU-JCAJVAELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 1β,2α,3β,11α-tetrahydroxyolean-12-ene 在 吡啶 作用下， 反应 2.0h， 生成 Acetic acid (4aR,6aS,6bR,8aS,10R,11R,12S,12aS,12bS,13R,14bR)-10,11-diacetoxy-12-hydroxy-2,2,4a,6a,6b,9,9,12a-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-picen-13-yl ester
  参考文献：
  名称：

  Terpenoids from Salvia kronenburgii

  摘要：

  A new norditerpenoid and six new triterpenoids were isolated from the roots of Salvia kronenburgii The new diterpenoid was kronenquinone (1). The new triterpenoids were 1 beta,2 alpha,3 beta,11 alpha-tetrahydroxy-olean-12-ene (2), 1 beta,2 alpha,3 beta,11 alpha-tetrahydroxy-urs-12-ene (3), 2 alpha-acetoxy-urs-5,12-diene-3 beta,11 alpha-diol (4), 3 alpha-acetoxy-urs-12-ene-1 beta,11 alpha-diol (5), 1 beta,3 alpha,11 alpha-trihydroxy-urs-12-ene (6), 2 alpha,3 beta,11 alpha-trihydroxy-urs-12-ene (7), and the known triterpenes 3 beta-acetoxy-urs-12-ene-1 beta,2 alpha,11 alpha-triol (8) and 3 beta-acetoxyolean-12-ene-1 beta,2 alpha,11 alpha-triol (9). Structures were determined by NMR and MS techniques.

  DOI：

  10.1021/np990165p

文献信息

• ACCELERATOR FOR INITIAL INSULIN SECRETION
  申请人：Use-Techno Corporation

  公开号：EP1674089A1

  公开（公告）日：2006-06-28

  The present invention provides an early insulin secretion stimulator consisting of a triterpene represented by the following general formula (1) and/or a triterpene represented by the following general formula (2). [where R1 represents COOH, etc., R11 and R12 represent CH2OH, etc., X1 represents hydrogen or OH and X11, X12, X21 and X22 represent OH, etc.]

  本发明提供了一种早期胰岛素分泌刺激剂，由以下通式（1）代表的三萜和/或以下通式（2）代表的三萜组成。 [其中 R1 代表 COOH 等，R11 和 R12 代表 CH2OH 等，X1 代表氢或 OH，X11、X12、X21 和 X22 代表 OH 等。］
• Insulin secretion potentiator
  申请人：Matsuyama Futoshi

  公开号：US20050143464A1

  公开（公告）日：2005-06-30

  The present invention provides early insulin secretion stimulators consisting of triterpenes represented by the following general formula (1) and/or triterpenes represented by the following general formula (2). [where R 1 represents COOH, etc., R 11 and R 12 represent CH 2 OH, etc., X 1 represents hydrogen or OH and X 11 , X 12 , X 21 and X 22 represent OH, etc.]