methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-7-[(diethyl(isopropyl)silyl)oxy]-2,14-dimethoxy-4,6,8,10-tetramethyl-14-[(4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]-2,4,10,12-tetradecatetraenoate | 174657-17-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-7-[(diethyl(isopropyl)silyl)oxy]-2,14-dimethoxy-4,6,8,10-tetramethyl-14-[(4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]-2,4,10,12-tetradecatetraenoate
• 英文别名: methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-7-[diethyl(propan-2-yl)silyl]oxy-2,14-dimethoxy-4,6,8,10-tetramethyl-14-[(4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]tetradeca-2,4,10,12-tetraenoate
• CAS: 174657-17-1
• 化学式: C₃₅H₆₂O₇Si
• 分子量: 622.959
• InChiKey: JEBGHBQECZWORW-DDDPENJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.38
• 重原子数：
  43
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl (2Z,4E,6R,7S,8S,10E)-7-[(diethyl(isopropyl)silyl)oxy]-11-iodo-2-methoxy-4,6,8,10-tetramethyl-2,4,10-undecatrienoate 、 methyl (1S,2E)-3-tributylstannyl-1-[(4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]-2-propenyl ether 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以60%的产率得到methyl (2Z,4E,6R,7S,8S,10E,12E,14S)-7-[(diethyl(isopropyl)silyl)oxy]-2,14-dimethoxy-4,6,8,10-tetramethyl-14-[(4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]-2,4,10,12-tetradecatetraenoate
  参考文献：
  名称：

  Stereoconvergent synthesis of C1–C17 and C18–C25 fragments of bafilomycin A1

  摘要：

  The effective syntheses of the enantiomerically pure C(1)-C(17) and C(18)-C(25) fragments as promising synthetic intermediates of bafilomycin A(1), I have been achieved. (C) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2007.11.091

文献信息

• Stereoconvergent synthesis of C1–C17 and C18–C25 fragments of bafilomycin A1
  作者：J.S. Yadav、K. Bhaskar Reddy、G. Sabitha

  DOI：10.1016/j.tet.2007.11.091

  日期：2008.2

  The effective syntheses of the enantiomerically pure C(1)-C(17) and C(18)-C(25) fragments as promising synthetic intermediates of bafilomycin A(1), I have been achieved. (C) 2007 Published by Elsevier Ltd.