(2E,4S,7E)-N-[[(1S,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl]methyl]-4,8,12-trimethyltrideca-2,7,11-trienamide | 1018781-54-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,4S,7E)-N-[[(1S,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl]methyl]-4,8,12-trimethyltrideca-2,7,11-trienamide
• CAS: 1018781-54-8
• 化学式: C₂₅H₄₂N₂O
• 分子量: 386.621
• InChiKey: FMHLRZRFYASTEB-GUXFVDFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,4S,7E)-N-[[(1S,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl]methyl]-4,8,12-trimethyltrideca-2,7,11-trienamide 、 碘甲烷 在 sodium dihydrogenphosphate 作用下， 以 甲醇 为溶剂， 以58%的产率得到(+)-stellettamide A
  参考文献：
  名称：

  Asymmetric Synthesis of Stellettamides A and C

  摘要：

  The first synthesis of the marine indolizidine alkaloids, (+)-stellettamide A and (-)-stellettamide C, has been achieved through a coupling reaction with the aminomethylindolizidine fragment and the chiral or achiral trienecarboxylic acid fragment, both of which could be derived from farnesol as a common precursor.

  DOI：

  10.3987/com-07-11211
• 作为产物：
  描述：

  (S,2E,7E)-4,8,12-trimethyltrideca-2,7,11-trienoic acid 、 (1S,8aR)-1-aminomethyl indolizidine 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以41%的产率得到(2E,4S,7E)-N-[[(1S,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl]methyl]-4,8,12-trimethyltrideca-2,7,11-trienamide
  参考文献：
  名称：

  Asymmetric Synthesis of Stellettamides A and C

  摘要：

  The first synthesis of the marine indolizidine alkaloids, (+)-stellettamide A and (-)-stellettamide C, has been achieved through a coupling reaction with the aminomethylindolizidine fragment and the chiral or achiral trienecarboxylic acid fragment, both of which could be derived from farnesol as a common precursor.

  DOI：

  10.3987/com-07-11211

文献信息

• Asymmetric Synthesis of Stellettamides A and C
  作者：Naoki Yamazaki、Takeshi Suzuki、Yuta Yoshimura、Chihiro Kibayashi、Sakae Aoyagi

  DOI：10.3987/com-07-11211

  日期：——

  The first synthesis of the marine indolizidine alkaloids, (+)-stellettamide A and (-)-stellettamide C, has been achieved through a coupling reaction with the aminomethylindolizidine fragment and the chiral or achiral trienecarboxylic acid fragment, both of which could be derived from farnesol as a common precursor.