丁苯酞杂质16 | 152567-80-1

• 物质功能分类: 分析化学 - 对照品
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 丁苯酞杂质16
• 中文别名: 丁苯酞杂质；丁苯酞标准品016
• 英文名称: 2-isovaleryl-benzoic acid
• 英文别名: 2¹-Oxo-2-isoamyl-benzol-carbonsaeure-(1)；Isovalerophenon-carbonsaeure-(2)；2-Isovaleryl-benzoesaeure；Benzoic acid, 2-(3-methyl-1-oxobutyl)-；2-(3-methylbutanoyl)benzoic acid
• CAS: 152567-80-1
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: UJBGRWNVLHJDRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丁苯酞杂质16 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 4-isobutyl-2H-phthalazin-1-one
  参考文献：
  名称：

  Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones

  摘要：

  A number of 4-substituted 2-[omega-(1-imidazolyl)allryl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane Az synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.

  DOI：

  10.1021/jm00077a008
• 作为产物：
  描述：

  3-亚异丁基苯酞 在 氢氧化钾 作用下， 生成 丁苯酞杂质16
  参考文献：
  名称：

  Bromberg, Chemische Berichte, 1896, vol. 29, p. 1436

  摘要：

  DOI：

文献信息

• Ruthenium-Catalyzed Enantioselective Hydrogenation/Lactonization of 2-Acylarylcarboxylates: Direct Access to Chiral 3-Substituted Phthalides
  作者：Bin Lu、Mengmeng Zhao、Guangni Ding、Xiaomin Xie、Lili Jiang、Virginie Ratovelomanana-Vidal、Zhaoguo Zhang

  DOI：10.1002/cctc.201700695

  日期：2017.10.23

  Synthesis of synthons: The asymmetric hydrogenation and subsequent in situ lactonization with Ru-diphosphines results in the direct conversion of a series of 2-acylarylcarboxylates including 2-aroylarylcarboxylates into the corresponding optically active 3-substituted phthalides under mild reaction conditions.

  合成子的合成：不对称氢化和随后用Ru-二膦进行原位内酯化可在温和的反应条件下将包括2-芳基芳基羧酸盐在内的一系列2-酰基芳基羧酸盐直接转化为相应的光学活性3-取代的邻苯二甲酸酯。
• Process for forming filled bearings from fluoropolymer dispersions stabilized with anionic polyelectrolyte dispersing agents
  申请人：Cavanaugh Robert John

  公开号：US20070281101A1

  公开（公告）日：2007-12-06

  The present invention provides a process for making a filled fluoropolymer bearing comprising providing an aqueous fluoropolymer dispersion comprising fluoropolymer particles and anionic polyelectrolyte dispersing agent in an amount sufficient for stabilization. The dispersion contains less than about 300 ppm fluorosurfactant based on the weight of the dispersion. The dispersion is coagulated to make a mush and a bearing filler is added to the dispersion prior to or after making the mush. The mush containing bearing filler is applied onto a bearing substrate to produce a coated substrate which is sintered and formed into a bearing.
• Concentrated fluoropolymer dispersions stabilized with anionic polyelectrolyte dispersing agents
  申请人：Cavanaugh Robert John

  公开号：US20070282044A1

  公开（公告）日：2007-12-06

  An aqueous fluoropolymer dispersion comprising fluoropolymer particles having an average particle size of about 10 to about 400 nm. The dispersion has a solids content of at least about 35 to about 70 wt % and comprises about 0.03 wt % to about 10 wt % anionic polyelectrolyte dispersing agent based on the weight of fluoropolymer solids. The dispersion has a Gel Time of at least about 100 seconds.
• US7294276B2
  申请人：——

  公开号：US7294276B2

  公开（公告）日：2007-11-13
• US7754287B2
  申请人：——

  公开号：US7754287B2

  公开（公告）日：2010-07-13