6-amino-1-(4-hydroxyphenyl)-8-methyl-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-amino-1-(4-hydroxyphenyl)-8-methyl-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 英文别名: 6-Amino-1-(4-hydroxyphenyl)-8-methyl-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• 化学式: C₂₂H₂₄N₄O₄
• 分子量: 408.457
• InChiKey: AQGRUBIRIQMMNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl chloride 在 镍 吡啶 、 氢溴酸 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 乙醚 、 乙醇 、 乙二醇甲醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 25.0~100.0 ℃ 、101.33 kPa 条件下， 反应 12.92h， 生成 6-amino-1-(4-hydroxyphenyl)-8-methyl-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  参考文献：
  名称：

  Studies on 6-Aminoquinolones:  Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones

  摘要：

  The 6-aminoquinolone had previously been identified as a new class of quinolone antibacterial agents. To continue our structure-activity relationship (SAR) study in this series, novel 6-amino-8-methylquinolone derivatives have now been synthesized and evaluated for in vitro antibacterial activity. We have shown that the coupled presence of a methyl group at the C-8 position with an amino group at C-6 is effective for enhancing antibacterial activity, particularly against Gram-positive bacteria. The SARs associated with the N-1, C-6, and C-7 are discussed. The 1,2,3,4-tetrahydroisoquinolinyl derivative 19v showed the highest antibacterial activity with MIC values on Gram-positive bacteria superior to that of ciprofloxacin, especially against Staphylococcus aureus strains, including those strains which are methicillin- and ciprofloxacin-resistant.

  DOI：

  10.1021/jm950558v

文献信息

• Studies on 6-Aminoquinolones:  Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones
  作者：Violetta Cecchetti、Arnaldo Fravolini、Maria Cristina Lorenzini、Oriana Tabarrini、Patrizia Terni、Tao Xin

  DOI：10.1021/jm950558v

  日期：1996.1.1

  The 6-aminoquinolone had previously been identified as a new class of quinolone antibacterial agents. To continue our structure-activity relationship (SAR) study in this series, novel 6-amino-8-methylquinolone derivatives have now been synthesized and evaluated for in vitro antibacterial activity. We have shown that the coupled presence of a methyl group at the C-8 position with an amino group at C-6 is effective for enhancing antibacterial activity, particularly against Gram-positive bacteria. The SARs associated with the N-1, C-6, and C-7 are discussed. The 1,2,3,4-tetrahydroisoquinolinyl derivative 19v showed the highest antibacterial activity with MIC values on Gram-positive bacteria superior to that of ciprofloxacin, especially against Staphylococcus aureus strains, including those strains which are methicillin- and ciprofloxacin-resistant.