丙二醇二硬脂酸酯 | 6182-11-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丙二醇二硬脂酸酯
• 中文别名: 1,2-丙二醇二硬脂酸酯；十八烷酸-1-甲基-1,2-乙二酯
• 英文名称: propylene glycol distearate
• 英文别名: 1,2-bis-stearoyloxy-propane；1,2-Bis-stearoyloxy-propan；propylene distearate；1,2-propanediol distearate；1.2-propanediol distearate；2-octadecanoyloxypropyl octadecanoate
• CAS: 6182-11-2
• 化学式: C₃₉H₇₆O₄
• 分子量: 609.03
• InChiKey: JEMDXOYRWHZUCG-UHFFFAOYSA-N

物化性质

• 沸点：
  640.5±28.0 °C(Predicted)
• 密度：
  0.896±0.06 g/cm3(Predicted)
• LogP：
  16.878 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  17.3
• 重原子数：
  43
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-phthalimido-ethyl)-phosphonic acid 、 丙二醇二硬脂酸酯 生成 DL-α-(α',β-Distearoyl)-glyceryl-2-amino-aethylphosphonat
  参考文献：
  名称：

  Rosenthal,A.F.; Pousada,M., Recueil des Travaux Chimiques des Pays-Bas, 1965, vol. 84, p. 833 - 839

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-丙二醇 、 十八烷酰氯 生成 丙二醇二硬脂酸酯
  参考文献：
  名称：

  Abderhalden; Eichwald, Chemische Berichte, 1914, vol. 47, p. 1859

  摘要：

  DOI：

文献信息

• CHELATE NANOEMULSION FOR MRI
  申请人：Port Marc

  公开号：US20130309176A1

  公开（公告）日：2013-11-21

  The present invention relates to an oil-in-water nanoemulsion composition for MRI, comprising: an aqueous phase, representing 70% to 90% by weight of the composition, advantageously 75% to 85% and more advantageously from 78% to 82% a lipid phase comprising an oil, representing 9.5% to 29.5% by weight of the composition, advantageously 14% to 25% and more advantageously 17% to 21%, a surfactant at the interface between the aqueous and lipid phases, the surfactant comprising at least one amphiphilic paramagnetic metal chelate and optionally an amphiphilic lipid; the total content of surfactant by weight relative to the oil being between 4% and 10% and advantageously between 5% and 8%; the total content of surfactant by weight relative to the composition being between 0.35% and 2.95% and advantageously between 0.5% and 2%; the oil comprising at least 70%, advantageously at least 80%, advantageously at least 95% by weight and especially at least 97% of saturated C6-C18, advantageously C6-C14 and more advantageously C6-C10 fatty acids.

  本发明涉及一种用于磁共振成像的油包水纳米乳液组合物，包括： 水相，表示组合物重量的70%至90%，优选75%至85%，更优选78%至82%； 脂相包括一种油，表示组合物重量的9.5%至29.5%，优选14%至25%，更优选17%至21%； 表面活性剂位于水相和脂相之间的界面上，表面活性剂包括至少一种两性磁性金属螯合物和可选的两性脂质； 相对于油的重量，表面活性剂的总含量在4%至10%之间，优选在5%至8%之间； 相对于组合物的重量，表面活性剂的总含量在0.35%至2.95%之间，优选在0.5%至2%之间； 油包括至少70%，优选至少80%，优选至少95%的饱和C6-C18，优选C6-C14，更优选C6-C10脂肪酸。
• Reaction of ethylene oxide or propylene oxide with long‐chain fatty acids. Mono‐ and diester formation
  作者：A. N. Wrigley、F. D. Smith、A. J. Stirton

  DOI：10.1007/bf02540263

  日期：1959.1

  The alkali‐catalyzed reaction of ethylene oxide or propylene oxide with fatty acids was shown to be complex. Mono‐ and diesters were formed in comparable amounts even at an early stage when only about one equivalent of the cyclic ether had been condensed.

  The following compounds were isolated in a pure state: ethylene glycol monolaurate, ethylene glycol dilaurate, diethylene glycol dilaurate, ethylene glycol distearate, 1,2‐propylene glycol dilaurate, and 1,2‐propylene glycol distearate. A monoester from propylene oxide was shown to be a mixture of the 1‐and 2‐monolaurate [C₁₁H₂₃CO₂CH₂CHOHCH₃ and C₁₁H₂₃CO₂CH(CH₃)CH₂OH].

  摘要环氧乙烷或环氧丙烷与脂肪酸的碱催化反应十分复杂。分离出下列纯化合物：乙二醇单月桂酸酯、乙二醇二月桂酸酯、二乙二醇二月桂酸酯、乙二醇二硬脂酸酯、1,2-丙二醇二月桂酸酯和 1,2-丙二醇二硬脂酸酯。研究表明，环氧丙烷单酯是 1 和 2-单月桂酸酯[C11H23CO2CH2CHOH 和 C11H23CO2CH(CH3)CH2OH]的混合物。
• Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules
  申请人：Chen Tongqian

  公开号：US20110092739A1

  公开（公告）日：2011-04-21

  The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).

  本发明涉及新型阳离子脂质体、转染剂、微粒子、纳米粒子和短干扰核酸（siNA）分子。本发明还涉及组合物和使用方法，用于研究、诊断和治疗对基因表达和/或活性调节有反应的特征、疾病和状况的主体或生物体。具体而言，本发明涉及能够有效转染或传递生物活性分子的新型阳离子脂质体、微粒子、纳米粒子和转染剂，例如抗体（例如单克隆、嵌合、人源化等）、胆固醇、激素、抗病毒药物、肽、蛋白质、化疗药物、小分子、维生素、辅因子、核苷、核苷酸、寡核苷酸、酶性核酸、反义核酸、三股形成寡核苷酸、2,5-A嵌合体、双链RNA、等亚型、适配体、诱饵和类似物，以及短干扰核酸（siNA）、短干扰RNA（siRNA）、双链RNA（dsRNA）、微RNA（miRNA）和短发夹RNA（shRNA）分子等小分子核酸分子，传递到相关的细胞和/或组织中，例如在主体或生物体中。这种新型阳离子脂质体、微粒子、纳米粒子和转染剂在提供用于预防、抑制或治疗细胞、主体或生物体中的疾病、状况或特征的组合物方面是有用的。本文所描述的组合物通常称为配制分子组合物（FMC）或脂质纳米粒子（LNP）。
• Skin care product containing hydroxyproline or N-acylated hydroxyproline derivatives
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1166767A2

  公开（公告）日：2002-01-02

  The present invention provides cosmetics comprising (1) hydroxyproline, an N-acylated hydroxyproline derivative or a salt thereof and (2) at least one component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high molecular peptides, high molecular polysaccharides, sphingolipids and seaweed extracts.

  本发明提供了包含以下成分的化妆品：（1）羟脯氨酸、N-酰化羟脯氨酸衍生物或其盐；（2）至少一种选自水溶性维生素、油溶性维生素、高分子肽、高分子多糖、鞘脂和海藻提取物的成分。
• OILY INGREDIENT FOR COSMETIC PREPARATION AND COSMETIC PREPARATION
  申请人：Kyowa Yuka Co., Ltd.

  公开号：EP1426041A1

  公开（公告）日：2004-06-09

  The present invention provides oils for cosmetics comprising a dibasic acid diester represented by general formula (I) (wherein R1, R2, R3 and R4, which are the same or different, each represent lower alkyl) and excellent in solubility of a long-wave ultraviolet light absorber or the like, and so forth.

  本发明提供了包含通式 (I) 所代表的二元酸二酯的化妆品油 (其中 R1、R2、R3 和 R4 相同或不同，各自代表低级烷基）的二元酸二酯。 并对长波紫外线吸收剂或类似物质具有极佳的溶解性等等。