丙二醇辛酸酯 | 68332-79-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丙二醇辛酸酯
• 英文名称: Octanoic acid;propane-1,2-diol
• CAS: 68332-79-6
• 化学式: C11H24O4
• 分子量: 220.31
• InChiKey: FSVSNKCOMJVGLM-UHFFFAOYSA-N

物化性质

• LogP：
  2.887 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 2-ACETYLNAPHTHO[2,3-B]FURAN -4,9-DIONE FOR USE ON TREATING CANCER
  申请人：BOSTON BIOMEDICAL, INC.

  公开号：US20160030384A1

  公开（公告）日：2016-02-04

  The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.

  这项发明提供了萘呋喃化合物，萘呋喃化合物的多晶形态，颗粒形式的萘呋喃化合物，含有一种或多种萘呋喃化合物的纯化组合物，含有一种或多种颗粒形式的萘呋喃化合物的纯化组合物，以及
• COMPOSITION CONTAINING A COMPOUND CAPABLE OF ESTABLISHING HYDROGEN BONDS, AND COSMETIC TREATMENT PROCESS
  申请人：CHODOROWSKI-KIMMES Sandrine

  公开号：US20100028277A1

  公开（公告）日：2010-02-04

  Composition containing, in a cosmetically or dermatologically acceptable medium, a compound that may be obtained by reaction between: an oil bearing at least one nucleophilic and/or electrophilic reactive function, and a junction group capable of establishing hydrogen bonds with one or more partner junction groups, the junction group bearing at least one reactive function capable of reacting with the reactive function borne by the oil, and also comprising at least one unit of formula (I) or (II):

  含有一种化合物的成分，可以通过以下反应获得：一个至少带有一个亲核和/或亲电反应功能的油，以及一个能够与一个或多个配对连接基建立氢键的连接基，该连接基至少带有一个能够与油所带反应功能发生反应的反应功能，并且还包括至少一个符合式(I)或(II)的单元的化妆品或皮肤学上可接受的介质。
• FORMULATION FOR ENHANCED TRANSDERMAL ABSORPTION OF DRUG
  申请人：UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

  公开号：US20190091168A1

  公开（公告）日：2019-03-28

  Provided is a transdermal formulation including a transdermal absorption enhancer including an aliphatic hydrocarbon derivative and a pyrrolidone derivative; and a benzene diamine derivative for preventing or treating dementia, Alzheimer's disease, and hair loss.

  提供的是一种透皮制剂，包括一种透皮吸收增强剂，其中包括一种脂肪族碳氢化合物衍生物和一种吡咯烷酮衍生物；以及一种苯二胺衍生物，用于预防或治疗痴呆症、阿尔茨海默病和脱发。
• Nitroalkene Trolox Derivatives and Methods of Use Thereof In The Treatment And Prevention of Inflammation Related Conditions
  申请人：Institut Pasteur de Montevideo

  公开号：US20180057475A1

  公开（公告）日：2018-03-01

  The present invention is directed to a class of anti-inflammatory, antioxidant nitroalkene compounds used in biological or biochemical applications to reduce oxidative stress or damage. The nitroalkene compounds described herein further avoid disadvantageous metabolism currently present in this field.

  本发明涉及一类抗炎、抗氧化的硝基烯烃化合物，用于生物或生物化学应用中减少氧化应激或损伤。本文描述的硝基烯烃化合物进一步避免了目前在该领域存在的不利代谢过程。
• [EN] LIQUID ORAL DOSAGE FORMULATIONS OF METHYLNALTREXONE<br/>[FR] FORMULATIONS POSOLOGIQUES ORALES LIQUIDES DE MÉTHYLNALTREXONE
  申请人：BAUSCH HEALTH IRELAND LTD

  公开号：WO2020225395A1

  公开（公告）日：2020-11-12

  Provided herein are pharmaceutical compositions comprising methylnaltrexone, lauryl sulfate or docusate, and at least one of an oil, a surfactant or a cosolvent, wherein the methylnaltrexone and lauryl sulfate or docusate are present as an ion pair. The pharmaceutical compositions may further comprise a surfactant so as to provide self-emulsifying methylnaltrexone delivery systems.

  本文提供了含有甲基纳曲酮、月桂酸十二烷基酯或多可酸盐，以及至少一种油、表面活性剂或共溶剂的制药组合物，其中甲基纳曲酮和月桂酸十二烷基酯或多可酸盐以离子对的形式存在。这些制药组合物还可能包含表面活性剂，从而提供自乳化的甲基纳曲酮传递系统。