丙氨酰-L-胱氨酸 | 115888-13-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙氨酰-L-胱氨酸
• 英文名称: N,N'-di-L-alanyl-L-cystine
• 英文别名: N,N'-Di-L-alanyl-L-cystin；N,N'-bis-L-alanyl-L-cystine；L-Alanyl-L-Cystine；(2R)-2-[[(2S)-2-aminopropanoyl]amino]-3-[[(2R)-2-[[(2S)-2-aminopropanoyl]amino]-2-carboxyethyl]disulfanyl]propanoic acid
• CAS: 115888-13-6
• 化学式: C₁₂H₂₂N₄O₆S₂
• 分子量: 382.462
• InChiKey: OEQVHDKNSGDYCV-XAMCCFCMSA-N

物化性质

• 沸点：
  751.7±60.0 °C(Predicted)
• 密度：
  1.445±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.8
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  235
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• METHOD FOR PRODUCING SUBSTANCE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2610338A1

  公开（公告）日：2013-07-03

  The present invention provides a medium suitable for animal cell culture, a culture method using the same, and the like. The present invention relates to a method for culturing animal cells having an ability to produce a substance, which comprises culturing the animal cells in a medium supplemented with an oligopeptide having one or more L-cysteines and excluding glutathione, a method for producing a substance by culturing animal cells having the ability to produce the substance, which comprises culturing the animal cells in a medium supplemented with an oligopeptide having one or more L-cysteines and excluding glutathione to produce and accumulate the substance in the culture, and collecting the substance from the culture, and a culture medium comprising an oligopeptide having one or more L-cysteines and excluding glutathione.

  本发明提供了一种适用于动物细胞培养的培养基、使用该培养基的培养方法等。本发明涉及一种培养具有产生物质的能力的动物细胞的方法，该方法包括在补充有一个或多个 L-半胱氨酸的寡肽且不包括谷胱甘肽的培养基中培养动物细胞；一种通过培养具有产生物质的能力的动物细胞来产生物质的方法，该方法包括在补充有一个或多个 L-半胱氨酸的寡肽且不包括谷胱甘肽的培养基中培养动物细胞、其中包括在补充有一个或多个 L-半胱氨酸且不含谷胱甘肽的寡肽的培养基中培养动物细胞，以在培养物中产生和积累该物质，并从培养物中收集该物质，以及包含有一个或多个 L-半胱氨酸且不含谷胱甘肽的寡肽的培养基。
• Cell culture medium comprising small peptides
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10793827B2

  公开（公告）日：2020-10-06

  Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells.

  提供了细胞培养基、浓缩培养基和饲料、细胞培养基和饲料的制造方法以及细胞培养方法。在细胞培养基中加入一种或多种小肽，包括二肽，可提高稳定性，改善细胞培养条件。
• Verwendung von N, N'-bis-L-Aminosäure-L-cystinpeptiden in Aminosäure-Präparaten für orale und parenterale Ernährung
  申请人：PFRIMMER KABI GMBH & CO. KG

  公开号：EP0264953B1

  公开（公告）日：1991-05-08
• CELL CULTURE MEDIUM COMPRISING SMALL PEPTIDES
  申请人：Life Technologies Corporation

  公开号：EP2561065A2

  公开（公告）日：2013-02-27
• METHOD OF CULTURING A CELL WITH A SUPPLEMENT
  申请人：Life Technologies Corporation

  公开号：US20170342371A1

  公开（公告）日：2017-11-30

  Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells.