3-exo-propyl-2-norbornanone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-exo-propyl-2-norbornanone
• 英文别名: 3-exo-Propyl-2-norbornanon；(1S,3S,4R)-3-propylbicyclo[2.2.1]heptan-2-one
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: BOKNHLKMBUHXGQ-VGMNWLOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-exo-propyl-2-norbornanone 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以59%的产率得到3-exo-propyl-2-endo-norbornanol
  参考文献：
  名称：

  2-Amino-2-oxazolines as Subtype Selective α₂ Adrenoceptor Agonists

  摘要：

  Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent alpha(2) adrenoceptor agonist, On the basis of a design generated by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of 1 was replaced by phenylalkyl subsituents. This resulted in compound 6 being an alpha(2c) selective agonist, as well as 7 and 9 being alpha(2a)/alpha(2c) selective.

  DOI：

  10.1021/jm9905256
• 作为产物：
  描述：

  降樟脑 、 1-碘代丙烷 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到3-exo-propyl-2-norbornanone
  参考文献：
  名称：

  2-Amino-2-oxazolines as Subtype Selective α₂ Adrenoceptor Agonists

  摘要：

  Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent alpha(2) adrenoceptor agonist, On the basis of a design generated by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of 1 was replaced by phenylalkyl subsituents. This resulted in compound 6 being an alpha(2c) selective agonist, as well as 7 and 9 being alpha(2a)/alpha(2c) selective.

  DOI：

  10.1021/jm9905256

文献信息

• Structures of the cmphene sultones
  作者：Joseph Wolinsky、Donald R. Dimmel、Thomas W. Gibson

  DOI：10.1021/jo01282a008

  日期：1967.7