retinyl linoleate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: retinyl linoleate
• 英文别名: [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoyl] (9Z,12Z)-octadeca-9,12-dienoate
• 化学式: C₃₈H₅₈O₃
• 分子量: 562.877
• InChiKey: NSPYSIMRMHHAAV-AOAPAXPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  41
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (Z,Z)-9,12-十八烷二烯酸二聚物 、 all-(E)-retinoic acetic anhydride 以 limonene. 为溶剂， 生成 retinyl linoleate
  参考文献：
  名称：

  Preparation of retinyl esters

  摘要：

  长链维生素A酯通过化学酶法从短链维生素A酯和适当的长链酸或酯在酶的存在下制备。使用各种添加剂可以提高所需酯的产量并促进其纯化。

  公开号：

  US20080085534A1

文献信息

• Methods for treatment of dermatological conditions
  申请人：Wang Bing

  公开号：US20050032751A1

  公开（公告）日：2005-02-10

  A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.

  本文揭示了一种通过含有本文所述的任何Formulae I或Ia化合物的局部组合物来减少与皮肤松弛、皮肤紧致度或眼部黑眼圈相关的皮肤状况的方法。
• Method and product for skin lightening
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20030044362A1

  公开（公告）日：2003-03-06

  A method and cosmetic product for lightening skin is provided, the method including wiping the skin with a cosmetic towelette. Impregnated on the towelette is an alpha-hydroxy carboxylic acid or salt thereof and a sunscreen agent.

  提供一种用于美白皮肤的方法和化妆品产品，该方法包括用化妆湿巾擦拭皮肤。湿巾上浸渍有α-羟基羧酸或其盐以及防晒剂。
• Chroman derivatives as lipoxygenase inhibitors
  申请人：Zhang Wei

  公开号：US20060193797A1

  公开（公告）日：2006-08-31

  The present invention is concerned with certain novel derivatives of Formula I: wherein X and R 1 to R 10 are as described in the specification, and where either R 5 is OH, —NR d OR a or —NR d —NR b R c , or R 7 is —NR d OR a or —NR d —NR b R c , or C═R 7 R 8 is C═NOR a or C═N—NR b R c , which may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful in the manufacture of skin care and/or pharmaceutical compositions for the treatment of lipoxygenase mediated disorders.

  本发明涉及Formula I的某些新颖衍生物：其中X和R1至R10如规范中所述，其中R5为OH，—NRdORa或—NRd—NRbRc之一，或R7为—NRdORa或—NRd—NRbRc之一，或C═R7R8为C═NORa或C═N—NRbRc，这些可能在制造用于治疗通过脂氧合酶介导的疾病的药物组合物中有用。它们还可能在制造用于治疗脂氧合酶介导疾病的皮肤护理和/或药用组合物中有用。
• [EN] NOVEL RETINOL DERIVATIVE AND COSMETIC COMPOSITION COMPRISING THE SAME<br/>[FR] NOUVEAU DERIVE DE RETINOL ET COMPOSITION COSMETIQUE COMPRENANT LEDIT DERIVE
  申请人：COREANA COSMETICS CO LTD

  公开号：WO2004054992A1

  公开（公告）日：2004-07-01

  The present invention relates to a novel retinol derivative and a cosmetic composition comprising the same, in particular, to a novel retinol derivative represented by the formula (I) exhibiting the effects from both L-ascorbic acid and retinol as well as being free from the disadvantages of two compounds such as skin irritation and instability in cosmetic formulation, and a cosmetic composition comprising the retinol derivative. (I)

  本发明涉及一种新型视黄醇衍生物和包含该衍生物的化妆品组合物，具体来说，涉及一种由式(I)表示的新型视黄醇衍生物，展现出L-抗坏血酸和视黄醇的双重效果，并且不具有两种化合物的缺点，如皮肤刺激和在化妆品配方中的不稳定性，以及包含该视黄醇衍生物的化妆品组合物。 (I)
• EXTENDED LONGEVITY FRAGRANCE DELIVERY COMPOSITION
  申请人：MOMENTIVE PERFORMANCE MATERIALS INC.

  公开号：US20160296459A1

  公开（公告）日：2016-10-13

  There is provided herein an extended longevity fragrance delivery composition which includes (a) acid-functional silicone, (b) fragrance, and; (c) water and/or organic solvent and, optionally, (d) at least one emulsifier or suspending agent, wherein acid-functional silicone (a) is present in a fragrance longevity-enhancing amount. There is also provided a process of making the fragrance delivery composition comprising combining (a)-(c) and optionally (d), applying the aqueous emulsion or suspension on a hair, skin, fabric or hard surface, and allowing the film to dry to form an ionically crosslinked film or residue which entraps the fragrance providing for long term fragrance effect to the hair, skin, fabric or hard surface.

  本文提供了一种延长香气释放时间的组合物，包含(a)酸性硅氧烷，(b)香料，以及(c)水和/或有机溶剂，可选地还包括(d)至少一种乳化剂或悬浮剂，其中酸性硅氧烷(a)以增强香气持久性的量存在。还提供了一种制备香气释放组合物的方法，包括混合(a)-(c)和可选的(d)，将水性乳液或悬浮液涂抹在头发、皮肤、织物或硬表面上，并允许薄膜干燥形成离子交联的薄膜或残留物，从而困住香气，实现长期的香气效果。