2-(12-oxobenzo[b]acridin-5(12H)-yl)acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(12-oxobenzo[b]acridin-5(12H)-yl)acetohydrazide
• 英文别名: 2-(12-Oxobenzo[b]acridin-5-yl)acetohydrazide；2-(12-oxobenzo[b]acridin-5-yl)acetohydrazide
• 化学式: C₁₉H₁₅N₃O₂
• 分子量: 317.347
• InChiKey: HRLXZJVVTAHIBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  D-吡喃木糖 、 a-无水葡萄糖酯 、 alpha-D-半乳糖 、 D-mannose 、 L-rhamnose 、 2-(12-oxobenzo[b]acridin-5(12H)-yl)acetohydrazide 、 L-arabinose 在 溶剂黄146 作用下， 以 乙腈 为溶剂， 生成 、 、 、 、 、
  参考文献：
  名称：

  Determination of the carbohydrates from Notopterygium forbesii Boiss by HPLC with fluorescence detection

  摘要：

  A sensitive pre-column derivatization method wasdeveloped for analysis of carbohydrates by HPLC with fluorescence detection. The introduction of 2-(12-benzo[b]acridin-5(12H)-yl)-acetohydrazide (BAAH) with excellent fluorescence property into the molecules of monosaccharides greatly enhanced the HPLC sensitivity of the analytes. Meanwhile, derivatization with BAAH also greatly increased the hydrophobicity of the monosaccharides and made them elute at increased retention times. The monosaccharides with similar properties therefore could be completely separated due to the increased interaction between the analytes and the column. Component monosaccharides of the polysaccharides obtained from the roots, stems and leaves of Notopterygium forbesii Boiss (NF) were analyzed by the developed method. The results indicated that the polysaccharides of NF were mainly composed of D-galactose and D-glucose. This is the first systematic study of the sugar composition of the polysaccharides of NF. It will be helpful for the quality control of NF. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2013.05.041