iodoethyl alcohol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 英文名称: iodoethyl alcohol
• 英文别名: iodoethanol；1-iodoethanol
• 化学式: C₂H₅IO
• 分子量: 171.966
• InChiKey: HZHWUOHAMYTSLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  iodoethyl alcohol 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)-ureido]phenyl}-6-(2-hydroxyethoxy)-1H-indole-2-carboxamide
  参考文献：
  名称：

  Substituted Indoles, Compositions Containing Them, Method for the Production Thereof and Their Use

  摘要：

  式(I)的化合物：其中R1、R5、R6、R7、Ar、L、A和Q如描述中所定义，并其盐，含有它们的组合物，制备它们的方法，以及它们作为药物的用途，特别是作为抗癌剂。

  公开号：

  US20070259910A1

文献信息

• [EN] BIARYL SUBSTITUTED PYRAZINONES AS SODIUM CHANNEL BLOCKERS<br/>[FR] PYRAZINONES SUBSTITUEES PAR BIARYLE UTILISEES COMME BLOQUANTS DES CANAUX SODIQUES
  申请人：MERCK & CO INC

  公开号：WO2005097136A1

  公开（公告）日：2005-10-20

  Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

  公式I所代表的取代联苯基吡嗪酮化合物，或其药学上可接受的盐。药物组合物包括有效量的即时化合物，单独或与一个或多个其他治疗活性化合物结合，并含有药学上可接受的载体。治疗与或由钠通道活性相关的病症的方法，例如急性疼痛、慢性疼痛、内脏疼痛、炎症性疼痛、神经痛、尿失禁、瘙痒、过敏性皮炎、癫痫、肠易激综合征、抑郁症、焦虑症、多发性硬化症和躁郁症，包括给予有效量的目前化合物，单独或与一个或多个其他治疗活性化合物结合。一种给予局部麻醉的方法包括给予即时发明的化合物的有效量，单独或与一个或多个其他治疗活性化合物结合，并含有药学上可接受的载体。
• Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
  申请人：——

  公开号：US20020107207A1

  公开（公告）日：2002-08-08

  The present invention provides an antiproliferative compound having a structural formula 1 where X and Y independently are oxygen, nitrogen or sulfur; R 1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitrites; R 2 and R 3 are hydrogen or R 4 ; R 4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R 5 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R 6 , wherein R 6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.

  本发明提供了一种具有结构式1的抗增殖化合物，其中X和Y独立地是氧、氮或硫；R1是烷基、烯基、炔基、芳基、杂环芳基、羧酸、羧酸盐、羧酰胺、酯、硫代酰胺、硫酸、硫酸酯、糖苷、烷氧基连接的糖苷、胺、磺酸盐、硫酸盐、磷酸盐、醇、醚或亚硝酸盐；R2和R3是氢或R4；R4是甲基、苄基羧酸、苄基羧酸盐、苄基羧酰胺、苄基酯、糖苷或胺；R5是烯基；其中当Y为氮时，所述氮被R6取代，其中R6是氢或甲基。还提供了治疗细胞增殖性疾病和诱导细胞凋亡的方法，包括给予该化合物。
• Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof
  申请人：Research Development Foundation

  公开号：US06417223B1

  公开（公告）日：2002-07-09

  The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.

  本发明提供了一种抗增殖化合物，其具有结构式，其中X为氧、氮或硫；R1为烷基、烯基、炔基、芳基、杂环芳基、羧酸、羧酸盐、羧酰胺、酯、硫代酰胺、硫酸、硫酸盐、磷酸、醇、醚和腈；R2为氢、甲基、苄基羧酸、苄基羧酸盐、苄基羧酰胺、苄酯、糖苷和胺；R3选自氢、甲基、苄基羧酸、苄基羧酸盐、苄基羧酰胺、苄酯、糖苷和胺的群体；R4为甲基、苄基羧酸、苄基羧酸盐、苄基羧酰胺、苄酯、糖苷和胺；R5为烷基、烯基、炔基、芳基、杂环芳基、羧基、酰胺和酯。还提供了一种诱导细胞凋亡的方法，包括给予含有该化合物的组合物。
• Phosphotriester type biologically active compounds
  申请人：——

  公开号：US05770725A1

  公开（公告）日：1998-06-23

  Compounds of formula RO--P(.dbd.O)(OR)--Nu where: each R is, independently, --(CH.sub.2).sub.n --S--X; X is --C(.dbd.Z) (Y) or --S--U; Z is O or S; Y and U are alkyl, aryl or saccharide groups optionally substituted with OH, SH or NH groups; n is 1 to 4; and Nu is a nucleoside which comprises a ribose or deoxyribose sugar portion covalently bound to a base portion.

  RO--P(.dbd.O)(OR)--Nu的化合物的公式，其中：每个R独立地是--(CH.sub.2).sub.n --S--X；X是--C(.dbd.Z) (Y)或--S--U；Z是O或S；Y和U是烷基、芳基或糖苷基，可选择性地取代为OH、SH或NH基团；n为1至4；Nu是包括与碱基部分共价结合的核苷的核苷酸，其中核苷包括核糖或去氧核糖糖部分。
• Benzoxazole derivatives
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：US05631257A1

  公开（公告）日：1997-05-20

  A benzoxazole derivative of the formula (1) or (2) which has an alicyclic diamine group at the 2-position: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X.sup.-, m and n are defined herein. The compound shows excellent 5-HT.sub.3 receptor antagonism and is useful as an antiemetic agent, a peristalsis controlling agent, an analgesic agent, an antianxiety agent and a schizophrenia treating agent.

  公式（1）或（2）的苯并噁唑衍生物，其在2-位置具有脂环二胺基团：其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6、X.sup.-、m和n在此处定义。该化合物表现出优异的5-HT.sub.3受体拮抗作用，并可用作抗恶心药、控制肠蠕动药、镇痛药、抗焦虑药和治疗精神分裂症的药物。