CPR 2001

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: CPR 2001
• 英文别名: DL-α-tocopheryl-6-O-phosphorylcholine；[2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] 2-(trimethylazaniumyl)ethyl phosphate
• 化学式: C₃₄H₆₂NO₅P
• 分子量: 595.844
• InChiKey: WDQLAOPAGWIYKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  41
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  DL-α-生育酚 在 水 、 三乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 60.0h， 生成 CPR 2001
  参考文献：
  名称：

  Synthesis of DL-α-tocopherol-ligated phospholipids

  摘要：

  A three-step synthesis of DL-alpha-tocopheryl-6-O-phosphorylcholine and its -6-O-phosphorylethanolamine homologue is described. The reaction pathway involves the conversion of DL-alpha-tocopherol to the corresponding 2-bromoethyl phosphate, hydrolytic cleavage of the remaining phosphorochloridate bond and treatment of the diester intermediate formed with either aqueous trimethylamine or ammonia to give the aminated target derivatives in good overall yields (61-67%). The compounds represent new models of ligated lipid mediators in which a vitamin E-unit is covalently bonded to a naturally occurring phospholipid fragment.

  DOI：

  10.1016/s0009-3084(97)00103-5

文献信息

• Synthesis of DL-α-tocopherol-ligated phospholipids
  作者：Stephan D. Stamatov

  DOI：10.1016/s0009-3084(97)00103-5

  日期：1998.2

  A three-step synthesis of DL-alpha-tocopheryl-6-O-phosphorylcholine and its -6-O-phosphorylethanolamine homologue is described. The reaction pathway involves the conversion of DL-alpha-tocopherol to the corresponding 2-bromoethyl phosphate, hydrolytic cleavage of the remaining phosphorochloridate bond and treatment of the diester intermediate formed with either aqueous trimethylamine or ammonia to give the aminated target derivatives in good overall yields (61-67%). The compounds represent new models of ligated lipid mediators in which a vitamin E-unit is covalently bonded to a naturally occurring phospholipid fragment.