2,6-dimethyl-6-vinyl-2-tetradecen-7-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,6-dimethyl-6-vinyl-2-tetradecen-7-ol
• 英文别名: 6-Ethenyl-2,6-dimethyltetradec-2-en-7-ol
• 化学式: C₁₈H₃₄O
• 分子量: 266.467
• InChiKey: QBGZCOYNGCSACM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  香叶基溴 、 正辛醛 在 锰 CrCl₂(THF) 、 2,4,6-collidine hydrochloride 、 1,2-双(二-异丙基膦基)乙烷 作用下， 以 四氢呋喃 为溶剂， 以98%的产率得到2,6-dimethyl-6-vinyl-2-tetradecen-7-ol
  参考文献：
  名称：

  ACID-MEDIATED, CHROMIUM-CATALYZED ALLYLATION OF ALDEHYDES

  摘要：

  Allyl bromides are efficiently coupled with aryl and aliphatic aldehydes in the presence of manganese metal, collidine hydrochloride, bis(diisopropylphosphino)ethane and chromium dichloride. Homoallylic alcohols are isolated in good to excellent yields directly from the reaction mixture.

  DOI：

  10.1081/scc-120004841

文献信息

• Samarium(II)-mediated reaction of allylic phosphate esters with carbonyl compounds: A new method for “Umpolung” of allylic phosphates
  作者：Shuki Araki、Masahiro Hatano、Hirokazu Ito、Yasuo Butsugan

  DOI：10.1016/s0022-328x(00)99810-3

  日期：1987.10

  Allylic phosphates allylate ketones and aldehydes in the presence of samarium(II) iodide. The coupling proceeds with the preservation of the olefin geometry, however, regio- and stereoselectivity are not high.

  烯丙基磷酸酯在碘化sa（II）的存在下使酮和醛烯丙基化。偶联随着烯烃几何形状的保持而进行，但是，区域选择性和立体选择性不高。
• ARAKI, SHUKI;HATANO, MASAHIRO;ITO, HIROKAZU;BUTSUGAN, YASUO, J. ORGANOMET. CHEM., 333,(1987) N 3, 329-335
  作者：ARAKI, SHUKI、HATANO, MASAHIRO、ITO, HIROKAZU、BUTSUGAN, YASUO

  DOI：——

  日期：——
• ACID-MEDIATED, CHROMIUM-CATALYZED ALLYLATION OF ALDEHYDES
  作者：Kevin H. Shaughnessy、Rongcai Huang

  DOI：10.1081/scc-120004841

  日期：2002.1

  Allyl bromides are efficiently coupled with aryl and aliphatic aldehydes in the presence of manganese metal, collidine hydrochloride, bis(diisopropylphosphino)ethane and chromium dichloride. Homoallylic alcohols are isolated in good to excellent yields directly from the reaction mixture.