2-(5-[1,2]dithiolan-3-yl-pentanoyloxy)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: 2-(5-[1,2]dithiolan-3-yl-pentanoyloxy)benzoic acid
• 英文别名: 2-[5-(Dithiolan-3-yl)pentanoyloxy]benzoic acid
• 化学式: C₁₅H₁₈O₄S₂
• 分子量: 326.438
• InChiKey: ORNUHFLPVVDQMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (R,S)-硫辛酰氯 、 水杨酸 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2-(5-[1,2]dithiolan-3-yl-pentanoyloxy)benzoic acid
  参考文献：
  名称：

  WO2006/66894

  摘要：

  公开号：

文献信息

• Anti-Inflammatory and Antioxidant Conjugates Useful for Treating Metabolic Disorders
  申请人：Mian Alec

  公开号：US20100234452A1

  公开（公告）日：2010-09-16

  The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.

  本发明涉及使用酯类化合物治疗代谢性疾病的方法。本发明的酯类化合物包括水杨酸、三氟沙利酸、二氟西纳酸、水杨酸盐、IMD-0354、布洛芬、双氯芬酸、利可酮或HTB，以及一种或多种抗氧化剂。
• Pharmaceutical Combinations Including Anti-Inflammatory and Antioxidant Conjugates Useful for Treating Metabolic Disorders
  申请人：Laria Julio Cesar Castro Palomino

  公开号：US20150025006A1

  公开（公告）日：2015-01-22

  One aspect of the present invention is a pharmaceutical combination comprising (a) an anti-inflammatory agent/anti-oxidant agent conjugate; and (b) an insulin secretogogue, an insulin sensitizer, an alpha-glucosidase inhibitor, a peptide analog, or a combination thereof. Another aspect of the invention relates to methods of treating metabolic disorders with such conjugates.

  本发明的一个方面是一种药物组合，包括（a）一种抗炎/抗氧化药物偶联物；以及（b）一种胰岛素分泌素、胰岛素敏感剂、α-葡萄糖苷酶抑制剂、肽类类似物或其组合。本发明的另一个方面涉及使用这种偶联物治疗代谢性疾病的方法。
• Anti-Inflammatory And Antioxidant Conjugates Useful For Treating Metabolic Disorders
  申请人：Genmedica Therapeutics SL

  公开号：US20130281520A1

  公开（公告）日：2013-10-24

  The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.

  本发明涉及使用化合物共轭物治疗代谢性疾病的方法。本发明的共轭物由水杨酸、三氟沙利、二氟沙利、水杨酸盐、IMD-0354、布洛芬、双氯芬酸、利可芬、或HTB以及一种或多种抗氧化剂组成。
• COMPOUNDS FOR TREATING METABOLIC SYNDROME
  申请人：Scherrer Urs

  公开号：US20090036516A1

  公开（公告）日：2009-02-05

  Compounds of general formula: wherein R′, R, x and z have the meaning reported in the specification, are useful for treating inflammatory diseases including metabolic syndrome, diabetes, obesity, dyslipidemia, and insulin resistance.

  通式为：其中R′、R、x和z的含义如规范中所述，对于治疗包括代谢综合征、糖尿病、肥胖症、血脂异常和胰岛素抵抗等炎症性疾病是有用的。
• Epoxidized esters of vegetable oil fatty acids as reactive diluents
  申请人：Bloom D. Paul

  公开号：US20060020062A1

  公开（公告）日：2006-01-26

  The present invention is directed to compositions containing epoxidized esters of vegetable oil fatty acids, and to methods of making such compositions. The esters are C 1-6 alkyl or C 2-6 alkenyl, monoglycerol or diglycerol, C 4-6 polyol or glycol esters of a vegetable oil fatty acid. The compositions include latex coating compositions comprising the epoxidized esters; epoxy resin compositions comprising the epoxidized esters; thermoset plastic compositions comprising the epoxidized esters; and PVC compositions comprising the epoxidized esters. The invention is also directed to epoxidized monoglycerides or diglycerides, and expoxidized C 4-6 polyol esters of vegetable oil fatty acids.

  本发明涉及含有植物油脂肪酸环氧化酯的组合物，以及制造这种组合物的方法。这些酯是 C 1-6 烷基或 C 2-6 烯基、单甘油或二甘油、C 4-6 多元醇或植物油脂肪酸乙二醇酯。这些组合物包括包含环氧化酯的乳胶涂料组合物；包含环氧化酯的环氧树脂组合物；包含环氧化酯的热固性塑料组合物；以及包含环氧化酯的聚氯乙烯组合物。本发明还涉及环氧化单甘油酯或双甘油酯，以及环氧化 C 4-6 植物油脂肪酸多元醇酯。