di-farnesyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: di-farnesyl hydrogen phosphate
• 英文别名: difarnesyl phosphate；bis[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] hydrogen phosphate
• 化学式: C₃₀H₅₁O₄P
• 分子量: 506.706
• InChiKey: HSFASFYXWFTGCW-SBEKHEBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  35
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  反式,反式-金合欢醇 在 吡啶 、 水 、 碘 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 生成 di-farnesyl hydrogen phosphate
  参考文献：
  名称：

  Sodium di-polyprenyl phosphates form “primitive” membranes

  摘要：

  The bis phosphoric esters of dimethylallyl alcohol, isopentenol, geraniol, farnesol and geranylgeraniol have been prepared through the phosphites in order to evalUate their phase properties in water. The sodium and calcium salts of the first two are soluble in water; the others easily form closed vesicles. These could be representative of "primitive" biomcmbranes.

  DOI：

  10.1016/s0040-4039(00)79146-5

文献信息

• Terpene synthases
  申请人：University of Kentucky Research Department

  公开号：EP2363458A2

  公开（公告）日：2011-09-07

  Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

  本文公开了新型合成酶和编码此类合成酶的相应核酸。此类合成酶具有一个活性位点袋，其中包括关键氨基酸残基，对这些氨基酸残基进行修饰可生成所需的萜类反应中间体和产物。合成酶的修饰是根据诸如烟草 5-表芳香烃合成酶的三维坐标设计的，活性位点中结合或不结合底物。
• Synthases
  申请人：The University of Kentucky Research Foundation, Kentucky corporation

  公开号：US20020040488A1

  公开（公告）日：2002-04-04

  Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

  本文公开了新型合成酶和编码此类合成酶的相应核酸。此类合成酶具有一个活性位点袋，其中包括关键氨基酸残基，对这些氨基酸残基进行修饰可生成所需的萜类反应中间体和产物。合成酶的修饰是根据诸如烟草 5-表芳香烃合成酶的三维坐标设计的，活性位点中结合或不结合底物。
• Nakatani, Yoichi; Plobeck, Niklas; Eifler, Stephane, Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 77, # 1-4, p. 125 - 128
  作者：Nakatani, Yoichi、Plobeck, Niklas、Eifler, Stephane、Brisson, Alain、Ourisson, Guy

  DOI：——

  日期：——
• Sodium di-polyprenyl phosphates form “primitive” membranes
  作者：Niklas Plobeck、Stéphane Eifler、Alain Brisson、Yoichi Nakatani、Guy Ourisson

  DOI：10.1016/s0040-4039(00)79146-5

  日期：1992.9

  The bis phosphoric esters of dimethylallyl alcohol, isopentenol, geraniol, farnesol and geranylgeraniol have been prepared through the phosphites in order to evalUate their phase properties in water. The sodium and calcium salts of the first two are soluble in water; the others easily form closed vesicles. These could be representative of "primitive" biomcmbranes.
• TERPENE SYNTHASES
  申请人：University of Kentucky Research Foundation

  公开号：EP1121422A2

  公开（公告）日：2001-08-08