3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid
• 英文别名: sapindoside G
• 化学式: C₆₃H₁₀₂O₂₈
• 分子量: 1307.49
• InChiKey: GCEPPDLZWOVSLB-BGHXYRABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.85
• 重原子数：
  91.0
• 可旋转键数：
  14.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  431.28
• 氢给体数：
  15.0
• 氢受体数：
  27.0

反应信息

• 作为反应物：
  描述：

  3-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 D-木糖 、 L-阿拉伯糖 、 L-鼠李糖 、 葡萄糖
  参考文献：
  名称：

  Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells

  摘要：

  Two new glycosides (1, 2) and two saponins (3, 4) were isolated from the fruits of Sapindus mukorossi Gaertn. The two glycosides were designated as sapindoside G (1) and 4,4-O-diacetylmukurozioside IIa (2). All four compounds exhibited inhibitory effects against A549 human lung adenocarcinoma cells with inhibition rates up to 69.2-83.3% at a concentration of 100g/mL. Flow cytometric analysis revealed that compounds 1-4 could suppress A549 cell growth by promoting cell apoptosis, which was related to the activation of caspase-3.[GRAPHICS].

  DOI：

  10.1080/14786419.2015.1054283

文献信息

• Two new glycosides isolated from <i>Sapindus mukorossi</i> fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells
  作者：Xuan-Ming Zhang、De-Po Yang、Zhi-Yong Xie、Qing Li、Long-Ping Zhu、Zhi-Min Zhao

  DOI：10.1080/14786419.2015.1054283

  日期：2016.7.2

  Two new glycosides (1, 2) and two saponins (3, 4) were isolated from the fruits of Sapindus mukorossi Gaertn. The two glycosides were designated as sapindoside G (1) and 4,4-O-diacetylmukurozioside IIa (2). All four compounds exhibited inhibitory effects against A549 human lung adenocarcinoma cells with inhibition rates up to 69.2-83.3% at a concentration of 100g/mL. Flow cytometric analysis revealed that compounds 1-4 could suppress A549 cell growth by promoting cell apoptosis, which was related to the activation of caspase-3.[GRAPHICS].