Diastereofacial selectivity in intermolecular nitrone cycloadditions to chiral allyl ethers. Application to Chiral Synthesis of Coniine
作者:Masayuki Ito、Masae Maeda、Chihiro Kibayashi
DOI:10.1016/0040-4039(92)80019-g
日期:1992.6
The intermolecular cycloadditions of a cyclic nitrone to chiral allyl ethers take place with erythro selectivity, where the degree of selectivity achieved is dependent upon the size of the alkyl substituent attached to the allylic chiral center, and these reactions are applied to the synthesis of optically active alkaloid coniine.
[EN] BIARYL PYRAZOLES AS NRF2 REGULATORS<br/>[FR] BIARYL PYRAZOLES UTILISÉS COMME RÉGULATEURS DE NRF2
申请人:GLAXOSMITHKLINE IP DEV LTD
公开号:WO2017060854A1
公开(公告)日:2017-04-13
The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
[EN] BETA-HYDROXY HETEROCYCLIC AMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA<br/>[FR] AMINES HÉTÉROCYCLIQUES BÊTA-HYDROXY ET LEUR UTILISATION DANS LE TRAITEMENT DE L'HYPERGLYCÉMIE
申请人:ATROGI AB
公开号:WO2019053425A1
公开(公告)日:2019-03-21
There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, ring A, m and n have meanings as provided in the description.
A Modified and Highly Useful Protocol for the Brønsted Acid Catalyzed, Enantioselective, Vinylogous Mannich Reaction with Aliphatic Aldimines
作者:Christoph Schneider、Falko Abels
DOI:10.1055/s-0031-1289303
日期:2011.12
Highly enantioselective as well as diastereoselective catalytic vinylogousMannichreactions have been accomplished for the first time with aliphatic straight-chain aldimines and O,O-silylketene acetals and furnish valuable synthetic building blocks in high enantiomeric purity. vinylogousMannichreaction - phosphoric acid - organocatalyis - contact ion pair - dienolate - BINOL
Asymmetric Allylboration of Cyclic Imines and Applications to Alkaloid Synthesis
作者:T. Robert Wu、J. Michael Chong
DOI:10.1021/ja0636791
日期:2006.8.1
Treatment of cyclic imines with 3,3'-disubstituted binaphthol modified allylboronates provides the expected allylated products in good yields and with high stereoselectivities (91-99% ee). The products may be readily transformed into various alkaloids.