di-β-elemene-13-yl succinate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: di-β-elemene-13-yl succinate
• 英文别名: bis[2-[(1R,3S,4S)-4-ethenyl-4-methyl-3-prop-1-en-2-ylcyclohexyl]prop-2-enyl] butanedioate
• 化学式: C₃₄H₅₀O₄
• 分子量: 522.769
• InChiKey: IPBQUJWAPZFPEL-IYNZBFDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  β-榄香烯 在 4-二甲氨基吡啶 、 sodium hypochlorite 、 溶剂黄146 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 di-β-elemene-13-yl succinate
  参考文献：
  名称：

  Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

  摘要：

  Forty beta-elemene derivatives were prepared and their antioxidant activity in H2O2-treated human umbilical vein endothelial cells (HUVECs) was first investigated. Among which, the dimer compounds 5r and 5s exhibited the most potent antioxidant activity against reactive oxygen species production. Meanwhile, 5r and 5s led to a significant increase in superoxide dismutase and nitric oxide levels and decrease in malonyldialdehyde and lactate dehydrogenase contents. Furthermore, KIT assay showed that 5r and 5s did not produce obvious cytotoxicity and had significantly cytoprotective effects against oxidative damage on HUVECs. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.078

文献信息

• Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives
  作者：Jichao Chen、Wenli Duan、Renren Bai、Hequan Yao、Jing Shang、Jinyi Xu

  DOI：10.1016/j.bmcl.2014.05.078

  日期：2014.8

  Forty beta-elemene derivatives were prepared and their antioxidant activity in H2O2-treated human umbilical vein endothelial cells (HUVECs) was first investigated. Among which, the dimer compounds 5r and 5s exhibited the most potent antioxidant activity against reactive oxygen species production. Meanwhile, 5r and 5s led to a significant increase in superoxide dismutase and nitric oxide levels and decrease in malonyldialdehyde and lactate dehydrogenase contents. Furthermore, KIT assay showed that 5r and 5s did not produce obvious cytotoxicity and had significantly cytoprotective effects against oxidative damage on HUVECs. (C) 2014 Elsevier Ltd. All rights reserved.