diethyl 2-hydroxy-6-methoxyazulene-1,3-dicarboxylate

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: diethyl 2-hydroxy-6-methoxyazulene-1,3-dicarboxylate
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.326
• InChiKey: VUCNKAINMFDSRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  环庚三烯酚酮 在 sodium ethanolate 、 potassium carbonate 、 四乙基对甲苯磺酸铵 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 43.0h， 生成 diethyl 2-hydroxy-6-methoxyazulene-1,3-dicarboxylate
  参考文献：
  名称：

  Electrochemical Methoxylation of 1,2,3-Trisubstituted Azulenes

  摘要：

  Abstract1,2,3‐Trisubstituted azulene analogs 6a and 6b easily underwent methoxylation in position 4 or 6 of an azulene ring via an electrochemical oxidation. It is a simple, convenient and selective method for introducing a methoxy group into a 7‐membered ring of azulene analogs when compared with traditional chemical methods. It could be useful in preparing 2,4‐ and 2,6‐azuloquinone analogs.

  DOI：

  10.1002/jccs.199900004

文献信息

• Electromethoxylation of diethyl 2-hydroxyazulene 1,3-dicarboxylate and 2-amino-1,3-dicyanoazulene
  作者：Arh-Hwang Chen、(the Late) Tetsuo Nozoe

  DOI：10.1016/s0040-4039(98)01632-3

  日期：1998.10

  A simple new method for methoxylation of 7-membered ring of 1,2,3-trisubstituted azulenes via electrooxidation is reported. It could be useful in preparing 2,4- and 2,6-azuloquinone analogs.

  报道了一种通过电氧化对1,2,3-三取代的天青烯的7元环进行甲氧基化的简单新方法。在制备2，4-和2，6-azuloquinone类似物时可能很有用。
• Electrochemical Methoxylation of 1,2,3-Trisubstituted Azulenes
  作者：Arh-Hwang Chen

  DOI：10.1002/jccs.199900004

  日期：1999.2

  Abstract1,2,3‐Trisubstituted azulene analogs 6a and 6b easily underwent methoxylation in position 4 or 6 of an azulene ring via an electrochemical oxidation. It is a simple, convenient and selective method for introducing a methoxy group into a 7‐membered ring of azulene analogs when compared with traditional chemical methods. It could be useful in preparing 2,4‐ and 2,6‐azuloquinone analogs.