邻硝基苯基BETA-D-葡萄糖醛酸苷 | 137629-36-8

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 邻硝基苯基BETA-D-葡萄糖醛酸苷
• 中文别名: 2-硝基苯基-Β-D-葡萄糖醛酸苷；邻硝基苯基-beta-D-吡喃葡萄糖醛酸苷；邻硝基苯基 BETA-D-葡萄糖醛酸苷
• 英文名称: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(2-nitrophenoxy)tetrahydro-2H-pyran-2-carboxylic acid
• 英文别名: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-nitrophenoxy)oxane-2-carboxylic acid
• CAS: 137629-36-8
• 化学式: C12H13NO9
• 分子量: 315.23
• InChiKey: UADVJQJTJSOJOQ-GOVZDWNOSA-N

物化性质

• 熔点：
  230-235°C
• 沸点：
  633.8±55.0 °C(Predicted)
• 密度：
  1.731±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于水

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  162
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 海关编码：
  29389090

文献信息

• Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
  申请人：FISONS plc

  公开号：EP0008864A1

  公开（公告）日：1980-03-19

  There are described compounds of formula I, in which R1 is phenyl substituted by halogen, alkoxy, alkyl, carboxy-alkyl, -NR4R5, carboxy or alkoxy carbonyl, R3 is hydrogen, alkyl, mono- or di-carboxy alkyl, halo, alkoxy, phenyl, halo-phenyl, hydroxy, phenoxy, thiol, thioalkoxy, thiophenoxy, -NR4Rs, cyano, -COOH, carboxyureido, -CF3, -CORe, hydroxyalkyl, aminoalkyl, or alkoxy substituted by NR4R5, ring A is a benzene or a pyridine ring which optionally carries up to 4 substituents R3, which may be the same or different, R4 and Rs, which may be the same or different, each represent hydrogen, phenyl, halophenyl or alkyl, the alkyl optionally being substituted by alkoxy or by a mono- or di- alkyl or unsubstituted amino group; or R4 and Rs, together with the nitrogen atom to which they are attached, form a piperidine, morpholine or an optionally alkyl substitued piperazine ring, and R6 is hydrogen or alkyl, provided that (i) when R, is phenyl substituted by chlorine or bromine, ring A is not a benzene ring substituted by chlorine or bromine, or (ii) when R, is phenyl substituted by methoxy R3 is not phenyl, and pharmaceutically acceptable salts, esters and amides thereof. There are also described methods for making the compounds and pharmaceutical, e.g. anti-inflammatory, compositions containing the compounds.

  所述化合物为式 I、 其中 R1 是被卤素、烷氧基、烷基、羧基、-NR4R5、羧基或烷氧基羰基取代的苯基、 R3 是氢、烷基、一羧基或二羧基烷基、卤素、烷氧基、苯基、卤代苯基、羟基、苯氧基、硫醇、硫代烷氧基、噻吩氧基、-NR4Rs、氰基、-COOH、羧基脲基、-CF3、-CORe、羟基烷基、氨基烷基或被 NR4R5 取代的烷氧基、 环 A 是苯环或吡啶环，可选择带有最多 4 个取代基 R3，它们可以相同或不同、 R4和Rs（可以相同或不同）各自代表氢、苯基、卤代苯基或烷基，烷基可选择被烷氧基或单烷基或二烷基或未取代的氨基取代；或R4和Rs与它们所连接的氮原子一起形成哌啶、吗啉或可选择被烷基取代的哌嗪环，以及 R6 为氢或烷基、 但 (i) 当 R 为被氯或溴取代的苯基时，环 A 不是被氯或溴取代的苯环，或 (ii) 当 R 为被甲氧基取代的苯基时，R3 不是苯基、 及其药学上可接受的盐、酯和酰胺。 此外，还介绍了制造这些化合物的方法以及含有这些化合物的药物组合物，例如消炎组合物。
• Chromogenic chemical substrates for identification of microbial colonies
  申请人：Rambach, Alain

  公开号：EP0025467A1

  公开（公告）日：1981-03-25

  Chromogenic substrate member for identifying Escherichia coli bacteria. It comprises a growing medium for said bacteria and container means (1) for the growing medium (4) and a liquid sample to be tested. The container means also contains a chromogenic reagent compound consisting in 8-hydroxyquinoline-β-D glucuronide and an activator compound consisting in X-glucuronide where X is selected from the group consisting in alkyl, aryl or indoxyl radical, the halogeno substitutes and the nitro substitutes thereof.

  用于鉴定大肠杆菌的致色底物部件。它包括一个供所述细菌生长的培养基和一个容器装置（1），用于盛放生长培养基（4）和待测液体样品。容器装置还包含由 8-羟基喹啉-β-D-葡萄糖醛酸组成的发色试剂化合物和由 X-葡萄糖醛酸组成的活化剂化合物，其中 X 选自烷基、芳基或吲哚基、其卤代物和硝基代物组成的组。
• Method and culture device for detecting yeasts and molds
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10640743B2

  公开（公告）日：2020-05-05

  A thin film culture device for detecting yeast and mold microorganisms in a sample is provided. The culture device comprises a body comprising a self-supporting substrate having a first major surface and a second major surface; a first adhesive composition disposed on a portion of the first major surface of the substrate; a substantially dry, cold-water-soluble first hydrogel-forming composition adhered to the first adhesive composition; and a plurality of indicator agents. The plurality of indicator agents comprises three indicator agents for detecting distinct glycosidase enzyme activities, an indicator agent for detecting an alkyl esterase enzyme activity, and an indicator agent for detecting a phosphatase enzyme activity, wherein each of the plurality of indicator agents comprises a detectable reporter group. A method of using the culture device is also provided.

  提供了一种用于检测样品中酵母和霉菌微生物的薄膜培养装置。该培养装置包括一个主体，该主体包括具有第一大表面和第二大表面的自支撑基底；设置在基底第一大表面部分上的第一粘合剂组合物；粘附在第一粘合剂组合物上的基本干燥、冷水可溶的第一水凝胶形成组合物；以及多种指示剂。多种指示剂包括三种用于检测不同糖苷酶酶活性的指示剂、一种用于检测烷基酯酶酶活性的指示剂和一种用于检测磷酸酶酶活性的指示剂，其中多种指示剂中的每一种都包括可检测的报告基团。还提供了一种使用该培养装置的方法。
• Method and composition for detecting bacterial contamination in food products
  申请人：Biocontrol Systems, Inc.

  公开号：US20020031796A1

  公开（公告）日：2002-03-14

  This invention relates to a method for detecting the existence or measuring the concentration of total viable bacteria in a test sample from a food product. A medium is provided which contains three or more different enzyme substrates each having a nutrient moiety and a detectable moiety linked together. When a substrate is hydrolysed by a bacterial enzyme to create a separate detectable moiety, it causes or produces a detectable signal. These substrates produce detectable signals when any one of a phosphatase enzyme, a glycosidase enzyme or a peptidase enzyme is present in the medium.

  本发明涉及一种检测食品测试样本中是否存在总存活细菌或测量其浓度的方法。提供了一种培养基，其中含有三种或三种以上不同的酶底物，每种底物都有一个营养分子和一个可检测分子连接在一起。当底物被细菌酶水解产生单独的可检测分子时，就会引起或产生可检测信号。当培养基中存在磷酸酶、糖苷酶或肽酶中的任何一种酶时，这些底物就会产生可检测信号。
• Detection of first generation environmental sourced microbes in an environmentally-derived sample
  申请人：——

  公开号：US20030190694A1

  公开（公告）日：2003-10-09

  The presence or absence of a predetermined target first generation environmental sourced microbe in an environmentally derived sample is determined by adding a testing medium to the sample, or vice versa. The testing medium provides a selective growth medium for the target microbe and includes a specific nutrient which only the target microbe can metabolize. This specific nutrient is modified by attaching a sample-altering moiety thereto, thereby converting the nutrient to a nutrient-indicator. The sample-altering moiety is activated to alter the sample only if the specific nutrient is metabolized by the target microbe. The sample-altering moiety can be a material which changes the color of the sample (visible or non-visible) or changes an electrical characteristic of the sample, or alters some other detectable characteristic of the sample. The testing media does not have to be kept sterile, and the testing procedure does not have to be performed in a sterile environment. The medium also includes an accelerant which hastens the advancement of the target microbes to the log phase of growth during the testing procedure.

  在环境样品中加入测试介质，或反之亦然，即可确定样品中是否存在预定的第一代环境源目标微生物。检测培养基为目标微生物提供了选择性生长培养基，其中包括只有目标微生物才能代谢的特定营养物质。这种特定的营养物质可通过附加样品改变分子进行改变，从而将营养物质转化为营养指标。只有当目标微生物代谢特定营养物质时，样品改变分子才会被激活，从而改变样品。样品改变分子可以是一种材料，它可以改变样品的颜色（可见或不可见），或改变样品的电特性，或改变样品的其他可检测特性。检测介质不必保持无菌，检测程序也不必在无菌环境中进行。培养基还包括一种促进剂，可在检测过程中加速目标微生物进入对数生长期。