1,3,4-triphenylhept-3E-3,6-dien-1-yne

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 1,3,4-triphenylhept-3E-3,6-dien-1-yne
• 英文别名: [(3E)-1,4-diphenylhepta-3,6-dien-1-yn-3-yl]benzene
• 化学式: C₂₅H₂₀
• 分子量: 320.434
• InChiKey: VWKMFGGVOYQYBZ-IZHYLOQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-氯乙炔基苯 、 3-溴丙烯 、 二苯基乙炔 在 Cp₂ZrEt₂ 、 copper(l) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 7.0h， 以75%的产率得到1,3,4-triphenylhept-3E-3,6-dien-1-yne
  参考文献：
  名称：

  Alkynylzirconation of Alkynes and Application to One-Pot Bisalkynylation of Alkynes

  摘要：

  Stereocontrolled alkynylzirconation of unactivated alkynes was achieved by the reaction of an alkyne with Cp2ZrEt2 and alkynyl halide in this order. After hydrolysis of the alkynylzirconation product, trisubstituted enyne derivatives were obtained in good yields. Functionalized enynes were also prepared by the reaction of the alkynylzirconation products with a variety of electrophiles. Subsequent addition of the second alkynyl halide to the alkynylzirconation products provided an in situ protocol for bisalkynylation of alkynes into (Z)-enediynes in good yields.

  DOI：

  10.1021/jo026037e

文献信息

• Alkynylzirconation of Alkynes and Application to One-Pot Bisalkynylation of Alkynes
  作者：Yuanhong Liu、Zhenqi Zhong、Kiyohiko Nakajima、Tamotsu Takahashi

  DOI：10.1021/jo026037e

  日期：2002.10.1

  Stereocontrolled alkynylzirconation of unactivated alkynes was achieved by the reaction of an alkyne with Cp2ZrEt2 and alkynyl halide in this order. After hydrolysis of the alkynylzirconation product, trisubstituted enyne derivatives were obtained in good yields. Functionalized enynes were also prepared by the reaction of the alkynylzirconation products with a variety of electrophiles. Subsequent addition of the second alkynyl halide to the alkynylzirconation products provided an in situ protocol for bisalkynylation of alkynes into (Z)-enediynes in good yields.