3,7-dimethyloct-6-en-1-yl 4-methylbenzoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,7-dimethyloct-6-en-1-yl 4-methylbenzoate
• 英文别名: 3,7-dimethyloct-6-enyl 4-methylbenzoate
• 化学式: C₁₈H₂₆O₂
• 分子量: 274.403
• InChiKey: ZGMWPWWANQGENL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,7-dimethyloct-6-en-1-yl 4-methylbenzoate 在 iron(III)-acetylacetonate 、 氧气 、 1,3,5-三羟基-1,3,5-三嗪-2,4,6(1H,3H,5H)-三酮 作用下， 以 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 以78%的产率得到
  参考文献：
  名称：

  一种烯丙基过氧化物的制备方法

  摘要：

  本发明提供了一种烯丙基过氧化物的制备方法，包括：在氮氧化物、金属催化剂和氧化剂的作用下，将烯丙基化合物在溶剂中进行反应，得到烯丙基过氧化物。本发明提供的方法具有转化率高、选择性好、环境污染小和后处理简单等优点。本发明可以在室温条件下，实现原料完全转化，过氧化物最高产率可达90％以上，以一锅法的方式可以进一步得到烯丙醇化合物，选择性极好。而且，本发明提供的方法具有很好的底物适应性和官能团耐受性，具有很强的实用性。

  公开号：

  CN111187131A
• 作为产物：
  描述：

  香茅醇 、 对甲基苯甲酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 3,7-dimethyloct-6-en-1-yl 4-methylbenzoate
  参考文献：
  名称：

  Effect of acyclic monoterpene alcohols and their derivatives on TRP channels

  摘要：

  A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 and/or IC50 values <1 mu M. None was able to significantly activate TRPM8 channels, while thirteen of them behaved as 'true' TRPM8 antagonists. Little or no effect was generally observed on TRPV1 channels. Some of the compounds examined, that is, compounds 1d, g, n, 2c, d, h, i, o, 3b, e exhibited an appreciable selectivity for TRPA1 subtype. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.10.012

文献信息

• Manganese/Cobalt Bimetallic Relay Catalysis for Divergent Dehydrogenative Difluoroalkylation of Alkenes
  作者：Tao Zhong、Chengyihan Gu、Yuhang Li、Jun Huang、Jian Han、Chengjian Zhu、Jie Han、Jin Xie

  DOI：10.1002/anie.202310762

  日期：2023.10.16

  The involvement of manganese radical for halogen atom transfer (XAT) reactions has been esteemed as one reliable method but encountered with limited catalytic models. In this paper, a novel bimetallic relay catalysis of Mn₂(CO)₁₀ and cobaloxime has been developed for divergent dehydrogenative difluoroalkylation of alkenes using commercially available difluoroalkyl bromides. A wide range of structurally diverse terminal, cyclic and internal alkenes as well as tetrasubstituted alkenes are found to be good coupling partners to deliver difluoroalkylated allylic products and difluoromethylated cyclic products, accompanied with the production of H₂ as the by‐product. This bimetallic relay strategy features broad substrate scope, mild reaction conditions and excellent functional group compatibility. Its success represents an important step‐forward to expedite the construction of a rich library of difluoroalkylated products.

  摘要锰自由基参与卤原子转移（XAT）反应一直被认为是一种可靠的方法，但催化模型有限。本文开发了一种新型的 Mn2(CO)10 和钴肟双金属接力催化法，用于使用市售的二氟烷基溴对烯烃进行歧化脱氢二氟烷基化反应。研究发现，多种结构不同的末端、环状和内部烯烃以及四取代烯烃都是良好的偶联伙伴，可提供二氟烷基化烯丙基产物和二氟甲基化环状产物，并产生 H2 作为副产品。这种双金属中继策略具有广泛的底物范围、温和的反应条件和出色的官能团兼容性。它的成功为加快构建丰富的二氟烷基化产物库迈出了重要一步。
• CHIRAL COMPOUNDS
  申请人：TAUGERBECK Andreas

  公开号：US20070229732A1

  公开（公告）日：2007-10-04

  The invention relates to chiral compounds of formula I wherein X 1 , X 2 , X 1 , X 2 , x 1 , x 2 , y 1 , y 2 , B, C, U 1 , U 2 , V 1 , V 2 , W 1 and W 2 have the meaning given in claim 1 , to liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.
• US7425356B2
  申请人：——

  公开号：US7425356B2

  公开（公告）日：2008-09-16
• Effect of acyclic monoterpene alcohols and their derivatives on TRP channels
  作者：Giorgio Ortar、Aniello Schiano Moriello、Enrico Morera、Marianna Nalli、Vincenzo Di Marzo、Luciano De Petrocellis

  DOI：10.1016/j.bmcl.2014.10.012

  日期：2014.12

  A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 and/or IC50 values <1 mu M. None was able to significantly activate TRPM8 channels, while thirteen of them behaved as 'true' TRPM8 antagonists. Little or no effect was generally observed on TRPV1 channels. Some of the compounds examined, that is, compounds 1d, g, n, 2c, d, h, i, o, 3b, e exhibited an appreciable selectivity for TRPA1 subtype. (C) 2014 Elsevier Ltd. All rights reserved.
• 一种烯丙基过氧化物的制备方法
  申请人：中国科学院长春应用化学研究所

  公开号：CN111187131A

  公开（公告）日：2020-05-22

  本发明提供了一种烯丙基过氧化物的制备方法，包括：在氮氧化物、金属催化剂和氧化剂的作用下，将烯丙基化合物在溶剂中进行反应，得到烯丙基过氧化物。本发明提供的方法具有转化率高、选择性好、环境污染小和后处理简单等优点。本发明可以在室温条件下，实现原料完全转化，过氧化物最高产率可达90％以上，以一锅法的方式可以进一步得到烯丙醇化合物，选择性极好。而且，本发明提供的方法具有很好的底物适应性和官能团耐受性，具有很强的实用性。