2-methoxy-4,6-dimethyl-quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-methoxy-4,6-dimethyl-quinoline
• 英文别名: 2-Methoxy-4,6-dimethyl-chinolin；2-Methoxy-4,6-dimethylquinoline
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: JDSLJIZRYCUTIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4'-甲基乙酰乙酰苯胺 在 甲醇 、 硫酸 、 三氯氧磷 作用下， 生成 2-methoxy-4,6-dimethyl-quinoline
  参考文献：
  名称：

  Substituted Lepidines¹

  摘要：

  DOI：

  10.1021/ja01208a035

文献信息

• INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC N-SUBSTITUTED PIPERAZINE DERIVATIVES
  申请人：Yeung Kap-Sun

  公开号：US20080132516A1

  公开（公告）日：2008-06-05

  This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is
• US8039486B2
  申请人：——

  公开号：US8039486B2

  公开（公告）日：2011-10-18
• Substituted Lepidines¹
  作者：C. E. Kaslow、N. B. Sommer

  DOI：10.1021/ja01208a035

  日期：1946.4