1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)prop-2-en-1-ol | 1491815-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)prop-2-en-1-ol
• 英文别名: 1-(1-methyl-3,4-dihydro-2H-quinolin-6-yl)prop-2-en-1-ol
• CAS: 1491815-50-9
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: NRSYHSDUSVUJTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  23.47
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-乙酰基环戊酮 、 1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)prop-2-en-1-ol 在 (11bS)-4-羟基-2,6-二[2,4,6-三(异丙基)苯基]-二萘并[2,1-d:1',2'-f][1,3,2]二氧杂磷杂卓4-氧化物 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 36.0h， 以30%的产率得到
  参考文献：
  名称：

  An Organocatalytic Asymmetric Allylic Alkylation Allows Enantioselective Total Synthesis of Hydroxymetasequirin-A and Metasequirin-B Tetramethyl Ether Diacetates

  摘要：

  The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates.

  DOI：

  10.1021/ol4037055
• 作为产物：
  描述：

  1-甲基-1,2,3,4-四氢喹啉-6-甲醛 、 乙烯基溴化镁 以 四氢呋喃 为溶剂， 反应 2.0h， 以91%的产率得到1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)prop-2-en-1-ol
  参考文献：
  名称：

  An Organocatalytic Asymmetric Allylic Alkylation Allows Enantioselective Total Synthesis of Hydroxymetasequirin-A and Metasequirin-B Tetramethyl Ether Diacetates

  摘要：

  The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates.

  DOI：

  10.1021/ol4037055

文献信息

• An Organocatalytic Asymmetric Allylic Alkylation Allows Enantioselective Total Synthesis of Hydroxymetasequirin-A and Metasequirin-B Tetramethyl Ether Diacetates
  作者：Pu-Sheng Wang、Xiao-Le Zhou、Liu-Zhu Gong

  DOI：10.1021/ol4037055

  日期：2014.2.7

  The first highly stereoselective organocatalytic intermolecular allylic alkylation of allylic alcohols with 1,3-dicarbonyls has been developed to allow the first enantioselective total synthesis of hydroxymetasequirin-A and metasequirin-B tetramethyl ether diacetates.