十六烷基丙酸酯 | 6221-96-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十六烷基丙酸酯
• 英文名称: hexadecyl propionate
• 英文别名: propionic acid hexadecyl ester；Propionsaeure-hexadecylester；Propionsaeure-n-hexadecylester；Cetylpropionat；cetyl propionate；hexadecyl propanoate
• CAS: 6221-96-1
• 化学式: C₁₉H₃₈O₂
• 分子量: 298.51
• InChiKey: RSRQBSGZMPVCOI-UHFFFAOYSA-N

物化性质

• 熔点：
  14.58°C (estimate)
• 沸点：
  339.91°C (estimate)
• 密度：
  0.8710 (estimate)
• LogP：
  8.428 (est)
• 保留指数：
  2079;2079;2081;2081;2085;2084;2068;2088

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  21
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915509000
• 储存条件：
  2-8°C

反应信息

• 作为产物：
  描述：

  1-十六烷醇 、 丙酰氯 以 二氯甲烷 为溶剂， 反应 3.0h， 以86%的产率得到十六烷基丙酸酯
  参考文献：
  名称：

  Esters, Retroesters, and a Retroamide of Palmitic Acid: Pool for the First Selective Inhibitors of N-Palmitoylethanolamine- Selective Acid Amidase

  摘要：

  Cyclohexyl hexadecanoate, hexadecyl propionate, and N-(3-hydroxypropionyl)pentadecanamide, respectively ester, retroester, and retroamide derivatives of N-palmitoylethanolamine, represent the first selective inhibitors of "N-palmitoylethanolamine hydrolase" described so far. These compounds are devoid of affinity for CB, and CB2 receptors and characterized by high percentages of inhibition of N-palmitoylethanolamine-selective acid amidase (84.0, 70.5, and 76.7% inhibition at 100 muM, respectively) with much lower inhibitory effect on either fatty acid amide hydrolase or the uptake of anandamide.

  DOI：

  10.1021/jm0340795

文献信息

• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• [EN] DIRECT DYES AND COMPOSITION COMPRISING THE DYES<br/>[FR] COLORANTS DIRECTS ET COMPOSITION LES COMPRENANT
  申请人：KAO GERMANY GMBH

  公开号：WO2016102207A1

  公开（公告）日：2016-06-30

  The present invention relates to novel direct dyes and compositions comprising them for dyeing keratin fibers especially human hair. The novel dyes of the present invention have benzothiophene structure providing intensive and homogeneous dyeing on keratin fibers, especially human hair.

  本发明涉及新型直接染料及包含它们的组合物，用于染色角蛋白纤维，特别是人类头发。本发明的新型染料具有苯并噻吩结构，在角蛋白纤维，特别是人类头发上提供强烈和均匀的染色。
• COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT
  申请人：PHOTOPROTECTIVE TECHNOLOGIES, INC.

  公开号：US20160317425A1

  公开（公告）日：2016-11-03

  A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.

  揭示了一种用于保护皮肤免受辐射有害影响的化合物、组合物和方法，特别是高能可见光（HEV）辐射的有害影响。该化合物是一种黑色素衍生物，可配制成含有该黑色素衍生物和适当载体的组合物。该组合物局部应用于皮肤，以减少光老化的风险并改善由辐射造成的皮肤修复。
• [EN] WATER SOLUBLE POLYMER COMPLEXES WITH SURFACTANTS<br/>[FR] COMPLEXES POLYMERES SOLUBLES DANS L'EAU COMPRENANT DES TENSIOACTIFS
  申请人：WSP CHEMICALS & TECHNOLOGY LLC

  公开号：WO2005099654A1

  公开（公告）日：2005-10-27

  A complex including a polymer and a surfactant formed by polymerizing a monomer mixture containing: (A) acid functional monomers at least partially neutralized with one or more amines according to one or more of formulas (I) through (IV): wherein R1 and R4 are independently a C8-C24 group; R2, R3 and R5 are independently H or a C1-C6 group, or where R2 and R3 combine to form an anelled ring of from 4 to 12 carbon atoms in length optionally containing hetero atoms; R6 is C1-C24 group, R7 is H or a C1-C12 group, and X is a halide, a sulfate or a sulfonate; (B) one or more cationic monomers; and optionally (C), one or more other monomers.

  由聚合物和表面活性剂形成的复合物，通过聚合含有单体混合物的单体混合物形成：（A）酸性官能单体，至少部分中和为一种或多种胺根据以下一个或多个公式（I）至（IV）：其中R1和R4独立地是C8-C24基团；R2、R3和R5独立地是H或C1-C6基团，或者其中R2和R3结合形成含有4至12个碳原子的环，可选地含有杂原子；R6是C1-C24基团，R7是H或C1-C12基团，X是卤化物、硫酸盐或磺酸盐；（B）一种或多种阳离子单体；和可选地（C），一种或多种其他单体。
• Isomerization of olefins with carboxylic acid
  申请人：——

  公开号：US20040249229A1

  公开（公告）日：2004-12-09

  A method of modifying the activity of a solid acid catalyst by contact with a carboxylic acid is presented. The modified catalyst is exposed to a feed mixture including olefins in a reaction zone, and an effluent including an isomerized olefin product is withdrawn from the reaction zone. The isomerized olefin product includes a more random distribution of internal olefins than the olefins of the feed mixture. The feed mixture and the isomerized olefin product include linear olefins. The isomerization results in no more than about 10 weight percent additional branched, compared to the olefins of the feed mixture, among the olefins of the isomerized olefin product. The isomerized olefin product includes no more than about 20 weight percent dimer. The olefin monomers of the feed mixture and the isomerized olefin product include from about 4 to about 30 carbon atoms. The effluent includes no more than about 20 weight percent ester. The solid acid catalyst may be an acidic ion exchange resin. The feed mixture may include olefins, esters, and carboxylic acid.

  提出了一种通过与羧酸接触来改变固体酸催化剂活性的方法。修改后的催化剂暴露于包括烯烃的进料混合物中的反应区域中，从反应区域中撤出包括异构烯烃产物的流出物。异构烯烃产物比进料混合物中的烯烃具有更随机的内部烯烃分布。进料混合物和异构烯烃产物包括线性烯烃。异构化导致异构烯烃产物中的烯烃中的支链不超过进料混合物中的烯烃的大约10重量百分比。异构烯烃产物中不含有超过大约20重量百分比的二聚体。进料混合物和异构烯烃产物中的烯烃单体包括大约4到30个碳原子。流出物中不含有超过大约20重量百分比的酯。固体酸催化剂可以是酸性离子交换树脂。进料混合物可以包括烯烃，酯和羧酸。