(2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-4-fluoro-3-methyl-octa-2,4,6-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-4-fluoro-3-methyl-octa-2,4,6-trienoic acid
• 英文别名: (2E,4Z,6Z)-7-[3,5-ditert-butyl-2-(2,2-difluoroethoxy)phenyl]-4-fluoro-3-methylocta-2,4,6-trienoic acid
• 化学式: C₂₅H₃₃F₃O₃
• 分子量: 438.53
• InChiKey: VKZJAKMQGKQVKR-UKWPUHOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-iodobut-2-enoic acid 、 Tributyl-{(1E,3Z)-4-[3,5-di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-1-fluoro-penta-1,3-dienyl}-stannane 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以81%的产率得到(2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-4-fluoro-3-methyl-octa-2,4,6-trienoic acid
  参考文献：
  名称：

  Design and synthesis of fluorinated RXR modulators

  摘要：

  Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the position of fluorination, and improvement in pharmacological profile was demonstrated in some cases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00703-0

文献信息

• Fluorinated trienes and their use as rxr modulators
  申请人：——

  公开号：US20040248919A1

  公开（公告）日：2004-12-09

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis. 1

  本发明涉及一种调节哺乳动物中视黄醇X受体活性的方法，用于调节哺乳动物中视黄醇X受体活性的新型化合物和制备调节哺乳动物中视黄醇X受体活性的化合物的方法。这些化合物由结构式1表示：结构式1的化合物是有效的胰岛素敏化剂，并且不具有增加三酰甘油或抑制甲状腺激素轴的不良副作用。
• FLUORINATED TRIENES AND THEIR USE AS RXR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1368296A1

  公开（公告）日：2003-12-10
• [EN] FLUORINATED TRIENES AND THEIR USE AS RXR MODULATORS<br/>[FR] TRIENES FLUORES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE RXR
  申请人：LILLY CO ELI

  公开号：WO2002072528A1

  公开（公告）日：2002-09-19

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.
• Design and synthesis of fluorinated RXR modulators
  作者：D.L. Gernert、R. Ajamie、R.A. Ardecky、M.G. Bell、M.D. Leibowitz、D.A. Mais、C.M. Mapes、P.Y. Michellys、D. Rungta、A. Reifel-Miller、J.S. Tyhonas、N. Yumibe、T.A. Grese

  DOI：10.1016/s0960-894x(03)00703-0

  日期：2003.10

  Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the position of fluorination, and improvement in pharmacological profile was demonstrated in some cases. (C) 2003 Elsevier Ltd. All rights reserved.