cis-1,2,3,5,6,7,8,8a-octahydro-1-(4-methoxyphenyl)-8a-methyl-2-phenyl-4-(trimethylsilyloxy)-quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: cis-1,2,3,5,6,7,8,8a-octahydro-1-(4-methoxyphenyl)-8a-methyl-2-phenyl-4-(trimethylsilyloxy)-quinoline
• 英文别名: [(2S,8aR)-1-(4-methoxyphenyl)-8a-methyl-2-phenyl-2,3,5,6,7,8-hexahydroquinolin-4-yl]oxy-trimethylsilane
• 化学式: C₂₆H₃₅NO₂Si
• 分子量: 421.655
• InChiKey: VZKLDNPDSKNCFE-AZGAKELHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.08
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-甲基环己-1-烯-1-基)乙酮 在 正丁基锂 、 四氯化钛 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 3.33h， 生成 cis-1,2,3,5,6,7,8,8a-octahydro-1-(4-methoxyphenyl)-8a-methyl-2-phenyl-4-(trimethylsilyloxy)-quinoline
  参考文献：
  名称：

  A novel hetero-Diels-Alder approach towards perhydro quinolinones bearing an angular methyl group

  摘要：

  The title compounds 9-11 were synthesized by a hetero Diels-Alder reaction using the sterically demanding diene 2 as a new building block. The effect of commonly used Lewis acids and the substitution pattern of various imines 5 on both the mechanism and the diastereoselectivity of the reaction with the diene is discussed and compared with data obtained by ab initio calculations. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10339-8

文献信息

• A novel hetero-Diels-Alder approach towards perhydro quinolinones bearing an angular methyl group
  作者：Peter Stanetty、Marko D Mihovilovic、Kurt Mereiter、Horst Völlenkle、Franz Renz

  DOI：10.1016/s0040-4020(97)10339-8

  日期：1998.1

  The title compounds 9-11 were synthesized by a hetero Diels-Alder reaction using the sterically demanding diene 2 as a new building block. The effect of commonly used Lewis acids and the substitution pattern of various imines 5 on both the mechanism and the diastereoselectivity of the reaction with the diene is discussed and compared with data obtained by ab initio calculations. (C) 1997 Elsevier Science Ltd. All rights reserved.