10,11-Diethoxy-N-[3-(4-methylpiperazin-1-YL)propyl]-5-oxo-7,8,12B,13-tetrahydro-5H-6-azatetraphene-13-carboxamide

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 10,11-Diethoxy-N-[3-(4-methylpiperazin-1-YL)propyl]-5-oxo-7,8,12B,13-tetrahydro-5H-6-azatetraphene-13-carboxamide
• 英文别名: 2,3-diethoxy-N-[3-(4-methylpiperazin-1-yl)propyl]-8-oxo-5,6,13,13a-tetrahydroisoquinolino[2,1-b]isoquinoline-13-carboxamide
• 化学式: C₃₀H₄₀N₄O₄
• mdl: MFCD14741027
• 分子量: 520.7
• InChiKey: ZNDQSLWMGZSNQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE
  申请人：Padmanabhan Radhakrishnan

  公开号：US20110224207A1

  公开（公告）日：2011-09-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• Flavivirus Inhibitors and Methods of Their Use
  申请人：Padmanabhan Radhakrishnan

  公开号：US20140038962A1

  公开（公告）日：2014-02-06

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• US8563580B2
  申请人：——

  公开号：US8563580B2

  公开（公告）日：2013-10-22
• US8906937B2
  申请人：——

  公开号：US8906937B2

  公开（公告）日：2014-12-09
• [FR] INHIBITEUR DE FLAVIVIRUS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV GEORGETOWN

  公开号：WO2010039538A2

  公开（公告）日：2010-04-08

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.