(E)-7-(3,7-dimethylocta-2,6-dienyl)-7-azabicyclo[4.1.0]heptane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (E)-7-(3,7-dimethylocta-2,6-dienyl)-7-azabicyclo[4.1.0]heptane
• 英文别名: 7-[(2E)-3,7-dimethylocta-2,6-dienyl]-7-azabicyclo[4.1.0]heptane
• 化学式: C₁₆H₂₇N
• 分子量: 233.397
• InChiKey: JEOICLGLMMKCRX-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  trans-2-azido-1-cyclohexanol 在 palladium(II) trifluoroacetate 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 (E)-7-(3,7-dimethylocta-2,6-dienyl)-7-azabicyclo[4.1.0]heptane
  参考文献：
  名称：

  Unusual Selectivity of Unprotected Aziridines in Palladium-Catalyzed Allylic Amination Enables Facile Preparation of Branched Aziridines

  摘要：

  Functionalized branched aziridines can be prepared in high yields and with high levels of regioselectivity using unprotected aziridines as nitrogen sources in palladium-catalyzed allylic amination. High levels of enantioselectivity can be achieved with BINAP on palladium. This methodology allows for strategic placement of an aziridine-containing fragment within a complex molecule environment for further elaboration.

  DOI：

  10.1021/ja049242f

文献信息

• Unusual Selectivity of Unprotected Aziridines in Palladium-Catalyzed Allylic Amination Enables Facile Preparation of Branched Aziridines
  作者：Iain D. G. Watson、Sarah A. Styler、Andrei K. Yudin

  DOI：10.1021/ja049242f

  日期：2004.4.28

  Functionalized branched aziridines can be prepared in high yields and with high levels of regioselectivity using unprotected aziridines as nitrogen sources in palladium-catalyzed allylic amination. High levels of enantioselectivity can be achieved with BINAP on palladium. This methodology allows for strategic placement of an aziridine-containing fragment within a complex molecule environment for further elaboration.