3-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-6-methyl-2-oxo-2H-pyran-4-yl difluoridoborate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-6-methyl-2-oxo-2H-pyran-4-yl difluoridoborate
• 化学式: C₁₇H₁₆BF₂NO₄
• 分子量: 347.126
• InChiKey: YMILSBFGDQXRSH-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  3-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-6-methyl-2-oxo-2H-pyran-4-yl difluoridoborate 在 sodium carbonate 作用下， 以 乙醇 、 水 为溶剂， 以83%的产率得到3-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-4-hydroxy-6-methyl-2H-pyran-2-one
  参考文献：
  名称：

  脱水乙酸二氟硼烷配合物的合成与反应

  摘要：

  Dehydracetic acid difluoroborane complex, 3-acetyl-6-methyl-2-oxo-2H-pyran-4-yl difluoridoborate, was synthesized and characterized. The complex was involved into condensation reactions at the acetyl group with various aromatic and heterocyclic aldehydes, and with the 4-dimethylaminobenzaldehyde it reacted also at the methyl group in the position 6.

  DOI：

  10.1134/s107042800807018x
• 作为产物：
  描述：

  3-acetyl-6-methyl-2-oxo-2H-pyran-4-yl difluoroborate 、 对二甲氨基苯甲醛 在 乙酸酐 作用下， 反应 0.5h， 以84%的产率得到3-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-6-methyl-2-oxo-2H-pyran-4-yl difluoridoborate
  参考文献：
  名称：

  Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase Inhibitors

  摘要：

  HIV-1 integrase (IN) has emerged as an important therapeutic target for anti-HIV drug development. Its uniqueness to the virus and its critical role in the viral life cycle makes IN suitable for selective inhibition. The recent approval of Raltegravir (MK-0518) has created a surge in interest and great optimism in the field. In our ongoing IN drug design research, we herein report the discovery of substituted analogs of 3-acetyl-4-hydroxy-2-pyranones and their difluoridoborate complexes as novel IN inhibitors. In many of these compounds, complexation with boron difluoride increased the potency and selectivity of IN inhibition. Compound 9 was most active with an IC50 value of 9 mu M and 3 mu M for 3'-processing and strand transfer inhibition, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.08.067