(6R,10R)-2,6,10,14-tetramethyl-7-methylenepentadeca-2,13-dien-8-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (6R,10R)-2,6,10,14-tetramethyl-7-methylenepentadeca-2,13-dien-8-one
• 英文别名: (6R,10R)-2,6,10,14-tetramethyl-7-methylidenepentadeca-2,13-dien-8-one
• 化学式: C₂₀H₃₄O
• 分子量: 290.489
• InChiKey: WWFOGCOHPOACCX-QZTJIDSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (+)-香茅醛 在 ethyl zinc isopropanolate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 7.0h， 生成 (6R,10R)-2,6,10,14-tetramethyl-7-methylenepentadeca-2,13-dien-8-one
  参考文献：
  名称：

  Organozinc alkoxide-promoted aldol-Tishchenko reaction of aliphatic aldehydes: an expedient entry to prepare the α-methylene ketones

  摘要：

  i-PrOZnEt is an excellent reagent to promote the aldol-Tishchenko reaction of the aliphatic aldehydes tethered with other labile functional groups. The 1,3-diol monoesters 4 were formed as the major products, which could be converted to alpha-methylene ketones 7 in two steps in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.076

文献信息

• Organozinc alkoxide-promoted aldol-Tishchenko reaction of aliphatic aldehydes: an expedient entry to prepare the α-methylene ketones
  作者：Yung-Son Hon、Chun-Ping Chang

  DOI：10.1016/j.tet.2005.03.076

  日期：2005.5

  i-PrOZnEt is an excellent reagent to promote the aldol-Tishchenko reaction of the aliphatic aldehydes tethered with other labile functional groups. The 1,3-diol monoesters 4 were formed as the major products, which could be converted to alpha-methylene ketones 7 in two steps in good yields. (c) 2005 Elsevier Ltd. All rights reserved.