四(亚磷酸三苯酯)镍 | 14221-00-2

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机镍
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 四(亚磷酸三苯酯)镍
• 中文别名: 四(三苯基亚磷酸盐)镍；四-(三磷酸三苯酯)镍(0)；三苯酚丙烯酸甲酯
• 英文名称: tetrakis(triphenylphosphite)nickel(0)
• 英文别名: Ni[P(OPh)₃]₄；nickel tetrakis(triphenylphosphite)；nickel;triphenyl phosphite
• CAS: 14221-00-2
• 化学式: C₇₂H₆₀NiO₁₂P₄
• 分子量: 1299.85
• InChiKey: PGXCIAAANFTEKX-UHFFFAOYSA-N

物化性质

• 熔点：
  145 °C (dec.)(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  21.8
• 重原子数：
  89
• 可旋转键数：
  24
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  12

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26,S36/37
• 危险类别码：
  R40,R36/37/38,R43
• WGK Germany：
  3
• 海关编码：
  29209090
• 储存条件：
  | 冰箱 (+4℃) |

SDS

Name:	Tetrakis(triphenyl phosphite)nickel(0) Material Safety Data Sheet
Synonym:
CAS:	14221-00-2

Section 1 - Chemical Product MSDS Name:Tetrakis(triphenyl phosphite)nickel(0) Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
14221-00-2	Tetrakis(triphenyl phosphite)nickel(0)		unlisted

Hazard Symbols: XN
Risk Phrases: 36/37/38 40 42/43

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact.Air sensitive.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
May cause sensitization by skin contact.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Possible risk of irreversible effects.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage:
Store in a tightly closed container. Keep refrigerated. (Store below 4C/39F.) Store under nitrogen.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 14221-00-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: tan
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 145 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C72H64NiO12P4
Molecular Weight: 1303.026

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of phosphorus, carbon dioxide, nickel oxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 14221-00-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Tetrakis(triphenyl phosphite)nickel(0) - California: carcinogen, initial date 5/7/04 (listed as Nickel compound NTP: Known carcinogen (listed as Nickel compounds).
IARC: Group 1 carcinogen (listed as Nickel compounds).

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 40 Limited evidence of a carcinogenic effect.
R 42/43 May cause sensitization by inhalation and
skin contact.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 14221-00-2: No information available.
Canada
CAS# 14221-00-2 is listed on Canada's NDSL List.
CAS# 14221-00-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 14221-00-2 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  四(亚磷酸三苯酯)镍 、 碘化氰 以 二氯甲烷 、 正戊烷 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Bobadilla, M.; Moran, M., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 9, p. 1069 - 1071

  摘要：

  DOI：
• 作为产物：
  描述：

  亚磷酸三苯酯 、 nickel(II) nitrate hexahydrate 在 sodium tetrahydroborate 作用下， 以 乙腈 为溶剂， 以46%的产率得到四(亚磷酸三苯酯)镍
  参考文献：
  名称：

  四面体镍（0）配合物的合成和发光性质

  摘要：

  四面体镍（0）络合物[NiL 4 ]，[Ni（dppe）2 ]和[Ni（CO）2（SbPh 3）2 ]（L = AsPh 3，SbPh 3，P（OPh）3，dppe = 1，通过在配体存在下在N 2或CO气氛下用NaBH 4还原NiCl 2 ·6H 2 O制备2-双（二苯基膦基）乙烷。NiCl 2 ·6H 2 O / SbPh 3体系在铂金丝网上于-1.3 V（Ag / Ag +）电解得到复合物[Ni（SbPh 3）4 ]。（摩尔比＝ 1：4）。这些复合物，无论是固态还是溶液，当被紫外线辐射激发时，在室温下均呈橙色发射。提出了[NiL 4 ]配合物的定性分子轨道图。配合物的电子吸收光谱显示出在400 nm附近的谱带，被指定为MLCTπ∗ 2e ←d 2t2。建议在这些系统中观察到的发射具有1 A 1 ← 3 T 1跃迁。根据时间分辨的发射光谱估算了微秒范围内的寿命。还研究了游离配体的光谱性质。

  DOI：

  10.1016/s0020-1693(96)05335-2
• 作为试剂：
  描述：

  2-(penta-1,2-dien-1-yl)-1-(phenylsulfonyl)-1H-indole 、 丙酮氰醇 在 四(亚磷酸三苯酯)镍 、 二苯基-2-吡啶膦 作用下， 以 甲苯 为溶剂， 反应 0.33h， 以53%的产率得到(E)-2-ethyl-4-(1-(phenylsulfonyl)-1H-indol-2-yl)but-3-enenitrile
  参考文献：
  名称：

  通过芳基烯丙基的区域和立体选择性氢氰化形式（±）-quebrachamine的形式合成

  摘要：

  本文介绍了基于1,3-二取代的烯基的区域和立体选择性氢氰化的邻苯二甲胺的形式合成。通过Ni催化的氢氰化作用有效地区分了烯基C C双键，并且CN基团被用作哌啶环的合成子。从HCN加合物开始的几个步骤提供了邻苯二甲酰胺的已知中间体。

  DOI：

  10.1016/j.tet.2018.04.044