奥比沙星杂质F(EP) | 106890-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 奥比沙星杂质F(EP)
• 英文名称: 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylic acid
• 英文别名: 1-Cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid；1-Cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid；1-cyclopropyl-5,6,7,8-tetrafluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 106890-70-4
• 化学式: C₁₃H₇F₄NO₃
• 分子量: 301.197
• InChiKey: RFZHFIFSQNIHAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  奥比沙星杂质F(EP) 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 7-(4-fluoro-2-isoindolinyl)-1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Isoindoline derivative

  摘要：

  公开了由公式（I）表示的异喹啉衍生物及其盐。根据残基R.sup.1-R.sup.9和X的类型，该化合物有许多种类。这些化合物可以由公式（II）的喹啉衍生物和公式（III）的异喹啉衍生物制备而成。公式（I）的化合物及其盐对革兰氏阳性和革兰氏阴性微生物具有出色的抗菌活性。它们可以用作药物、农药和食品防腐剂。

  公开号：

  US05026856A1
• 作为产物：
  描述：

  ethyl 1-cyclopropyl-5,6,7,8-tetrafluoro-4(1H)-oxoquinoline-3-carboxylate 在 硫酸 作用下， 以80%的产率得到奥比沙星杂质F(EP)
  参考文献：
  名称：

  Synthesis of novel 5-fluoro analogs of norfloxacin and ciprofloxacin

  摘要：

  A series of polyfluoro-3-quinolonecarboxylic acids have been synthesized and their in vitro antibacterial activity evaluated. The desired 7-(substituted amino) derivatives were prepared from the 5,6,7,8-tetrafluoroquinolone acids. Conversely, amine displacement occurred primarily at the 5-position when the ester was used. Structure-activity studies indicated that the antibacterial activity was greatest when the N-1 substituent was cyclopropyl and the 7-substituent was 4-methyl-1-piperazinyl. All 5-(substituted amino) derivatives showed poor in vitro activity.

  DOI：

  10.1021/jm00126a028

文献信息

• Aminoquinolones as GSK-3 inhibitors
  申请人：Cociorva Oana

  公开号：US20070254866A1

  公开（公告）日：2007-11-01

  Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.

  本文提供了氨基喹啉及其药用可接受的衍生物。在某些实施例中，本文提供了用于治疗、预防或改善GSK-3介导疾病的化合物、组合物和方法。
• 7-isoindolinyl-naphthyridone derivatives, compositions and
  申请人：Bayer Aktiengesellschaft

  公开号：US05556979A1

  公开（公告）日：1996-09-17

  The invention relates to novel quinolone derivatives and naphthyridone derivatives which are substituted in the 7-position by a partially hydrogenated isoindolinyl ring, to processes for their preparation and to antibacterial agents and feed additives containing them.

  该发明涉及新颖的喹诺酮衍生物和萘啶酮衍生物，它们在7位被部分氢化的异吲哚基环取代，以及它们的制备方法、含有它们的抗菌剂和饲料添加剂。
• Quinolonecarboxylic acids
  申请人：Bayer Aktiengesellschaft

  公开号：US05480879A1

  公开（公告）日：1996-01-02

  The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.

  该发明涉及与β-内酰胺抗生素相连的喹诺酮羧酸和萘啶羧酸的新型衍生物，以及它们的盐、制备过程和含有这些衍生物的抗菌剂。
• Anti-bacterial quinolone- and naphthyridone-carboxylic acid compounds
  申请人：Korea Research Institute of Chemical Technology

  公开号：US05091384A1

  公开（公告）日：1992-02-25

  Quinolone compounds of the general formula ##STR1## pharmaceutical compositions active against bacterial infections containing such compounds, processes for the manufacture of the quinolone compounds and the compositions and the use of the quinolone compounds for the manufacture of pharmaceutical compositions for the treatment of bacterial infections.

  通用公式为##STR1##的喹诺酮化合物，用于抗击细菌感染的药物组合物，包含这些化合物，制造喹诺酮化合物和组合物的工艺，以及利用喹诺酮化合物制造用于治疗细菌感染的药物组合物。
• Quinolone compounds and a process for their preparation
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0424850A1

  公开（公告）日：1991-05-02

  Quinolone compounds of the general formula pharmaceutical compositions active against bacterial infections containing such compounds, processes for the manufacture of the quinolone compounds and the compositions and the use of the quinolone compounds for the manufacture of pharmaceutical compositions for the treatment of bacterial infections.

  通式喹诺酮化合物的药物组合物对抗细菌感染具有活性，包含这种化合物，制造喹诺酮化合物和组合物的过程以及利用喹诺酮化合物制造用于治疗细菌感染的药物组合物。