(2-甲氧基苯基)亚膦酰二氯 | 58325-49-8

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: (2-甲氧基苯基)亚膦酰二氯
• 英文名称: 2-anisyldichlorophosphine
• 英文别名: Dichloro-(o-methoxyphenylphosphin)；Dichlor-(2-methoxy-phenyl)-phosphin；dichloro(2-methoxyphenyl)phosphine；2-Methoxy(dichlorophosphino)benzene；dichloro-(2-methoxyphenyl)phosphane
• CAS: 58325-49-8
• 化学式: C₇H₇Cl₂OP
• 分子量: 209.012
• InChiKey: LVMVDEGJLXVJST-UHFFFAOYSA-N

物化性质

• 沸点：
  267.9±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-溴茴香硫醚 、 (2-甲氧基苯基)亚膦酰二氯 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 以71.6%的产率得到(2-methoxyphenyl)bis(4-thiomethylphenyl)phosphine
  参考文献：
  名称：

  2-Thioanisyldichlorophosphine, new starting material for the preparation of multidentate phosphine ligands: syntheses and characterization of derivatives of 2-anisyl- and 2-thioanisyldichlorophosphines

  摘要：

  A new aryldichlorophosphine, 2-thioanisyldichlorophosphine, and its anisyl analogue, 2-anisyldichlorophosphine, were prepared by using an organozinc halide reagent of 2-thioanisole or 2-anisole with ethereal solution of PCl3 in refluxing conditions. From these aryldichlorophosphines, eight new multidentate phosphine ligands containing 2-thioanisyl, 4-thioanisyl, 2-anisyl, 1-naphthyl and 9-anthracenyl groups were synthesized and characterized. Characterization was based mainly on NMR spectroscopy and X-ray crystallography. The crystal structures of six ligands are reported. The electronic effects on basicity of ligands are discussed. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(99)00711-1
• 作为产物：
  描述：

  2-溴苯甲醚 在 正丁基锂 、 zinc(II) chloride 、 三氯化磷 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 24.0h， 以37.4%的产率得到(2-甲氧基苯基)亚膦酰二氯
  参考文献：
  名称：

  2-Thioanisyldichlorophosphine, new starting material for the preparation of multidentate phosphine ligands: syntheses and characterization of derivatives of 2-anisyl- and 2-thioanisyldichlorophosphines

  摘要：

  A new aryldichlorophosphine, 2-thioanisyldichlorophosphine, and its anisyl analogue, 2-anisyldichlorophosphine, were prepared by using an organozinc halide reagent of 2-thioanisole or 2-anisole with ethereal solution of PCl3 in refluxing conditions. From these aryldichlorophosphines, eight new multidentate phosphine ligands containing 2-thioanisyl, 4-thioanisyl, 2-anisyl, 1-naphthyl and 9-anthracenyl groups were synthesized and characterized. Characterization was based mainly on NMR spectroscopy and X-ray crystallography. The crystal structures of six ligands are reported. The electronic effects on basicity of ligands are discussed. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(99)00711-1

文献信息

• General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse <i>P</i>-Stereogenic Secondary Phosphine Oxides
  作者：Zhengxu S. Han、Hao Wu、Yibo Xu、Yongda Zhang、Bo Qu、Zhibin Li、Donald R. Caldwell、Keith R. Fandrick、Li Zhang、Frank Roschangar、Jinhua J. Song、Chris H. Senanayake

  DOI：10.1021/acs.orglett.7b00568

  日期：2017.4.7

  A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alcohol templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis.

  描述了通过使用容易获得的手性氨基醇模板合成庞大且结构多样的P-立体异构的手性仲膦氧化物（SPO）的通用且有效的方法。这些手性SPO可用作合成难于获得的庞大的P - stereogenic膦化合物或有机催化配体的手性构件。
• Development of Practical Rhodium Phosphine Catalysts for the Hydrogenation of β-Dehydroamino Acid Derivatives
  作者：Stephan Enthaler、Giulia Erre、Kathrin Junge、Jens Holz、Armin Börner、Elisabetta Alberico、Ilenia Nieddu、Serafino Gladiali、Matthias Beller

  DOI：10.1021/op0602270

  日期：2007.5.1

  The rhodium-catalyzed asymmetric hydrogenation of various β-dehydroamino acid derivatives to give optically active β-amino acids has been examined. Chiral monodentate 4,5-dihydro-3H-dinaphthophosphepines, which are easily tuned and accessible in a multi-10-g scale, have been used as ligands. The enantioselectivity is largely dependent on the nature of the substituent at the phosphorous atom and on

  已经研究了铑催化的各种β-脱氢氨基酸衍生物的不对称氢化，以产生光学活性的β-氨基酸。手性单齿4,5-二氢-3 H-二萘并吡啶类易配体已被轻松调配，并且可在多至10 g的范围内使用。对映选择性主要取决于磷原子上取代基的性质以及底物的结构。应用了高达94％ee的优化条件。
• [EN] PROCESS FOR TELOMERIZATION OF BUTADIENE USING A MONO-ORTHOALKOXY SUBSTITUTED CATALYST<br/>[FR] PROCÉDÉ DE TÉLOMÉRISATION DU BUTADIÈNE AU MOYEN D'UN CATALYSEUR MONOSUBSTITUÉ EN ORTHO AVEC UNE ALCOXY
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2012087686A1

  公开（公告）日：2012-06-28

  A process for the telomerization of butadiene comprises reacting 1,3-butadiene and an alkanol, in the presence of a catalyst promoter and an alkoxydimerization catalyst comprising a Group VIII transition metal and a triarylphosphine ligand, which includes one phenyl that is mono-ortho-alkoxy substituted and at least one other phenyl including at least one substituent that withdraws electrons from the phosphorus atom. The product includes an alkoxy-substituted octadiene, which may then be used to produce 1-octene. The catalyst shows improved stability, activity and selectivity toward the alkoxy-substituted octadiene.

  一种丁二烯的缩聚反应过程包括在催化剂促进剂和一种包括第VIII族过渡金属和三芳基膦配体的烷氧二聚化催化剂存在下，将1,3-丁二烯和烷醇反应。该配体包括一个苯基，其单位于邻位烷氧基取代，以及至少另一个苯基，其中至少有一个取代基从磷原子中提取电子。产物包括烷氧取代的辛二烯，随后可用于生产1-辛烯。该催化剂表现出对烷氧取代的辛二烯的改进稳定性、活性和选择性。
• METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE
  申请人：Baumann Robert

  公开号：US20090281356A1

  公开（公告）日：2009-11-12

  Method of producing compounds of the general formula XPR 2 (OR 1 )  I a where X is chlorine, bromine or iodine and R 1 is an organic radical, by reacting compounds of the general formula X 2 PR 2 II, in which X has the meaning given above and R 2 is an organic radical, with compounds of the general formula R 1 OH  III, in which R 1 has the meaning given above, to give a mixture IV, in that a) the postreaction is carried out at a temperature of from 50 to 240° C. and a pressure of from 0.001 to 0.9 bar, b) from the mixture IV the compounds I a are separated off from the compounds PR 2 (OR 1 ) 2 I b and, if appropriate, the compounds II and c) compounds I b and, if appropriate, unreacted compounds II are returned to the synthesis stage.

  通过将通式为X2PR2 II（其中X具有上述给定的含义，R2是有机基团）的化合物与通式为R1OH III（其中R1具有上述给定的含义）反应，得到混合物IV，从而生产通式为XPR2（OR1）Ia的化合物的方法，其中X是氯、溴或碘，R1是有机基团，具体步骤如下： a）在50至240℃的温度和0.001至0.9巴的压力下进行反应； b）从混合物IV中分离出化合物Ia和化合物PR2（OR1）2 Ib，必要时还包括化合物II； c）将化合物Ib和必要时未反应的化合物II返回到合成阶段。
• METHODS FOR PREPARING ARYLPHOSPHINE-BORANE COMPLEXES
  申请人：Dow Global Technologies LLC

  公开号：US20210380613A1

  公开（公告）日：2021-12-09

  A method for preparing phosphine-borane complexes from aryldihalophosphine includes mixing sodium borohydride, a solvent having at least 50 vol % glycol ethers, and the aryldihalophosphine to obtain a solution. The solution is maintained at a reaction temperature for a duration of time to obtain the phosphine-borane complexes. The solvent may include 1,2-dimethoxyethane and tetrahydrofuran. A ratio of tetrahydrofuran to 1,2-dimethoxyethane in the solvent may be from 0.1:1.0 to 2.5:1.0.

  一种制备膦硼烷配合物的方法，包括混合硼氢化钠、至少含有50体积％的乙二醇醚溶剂和芳基二卤代膦，以获得溶液。将该溶液维持在反应温度下一定的时间，以获得膦硼烷配合物。该溶剂可以包括1,2-二甲氧基乙烷和四氢呋喃。溶剂中四氢呋喃与1,2-二甲氧基乙烷的比例可以从0.1:1.0到2.5:1.0。